These common heterocyclic compound, 1080-74-6, name is 2-(3-Oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 2-(3-Oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile
Then F (1.07 g, 1.5 mmol) was dissolved in chloroform.G (1.16g 6mmol) was added and 1mL of pyridine was added as a catalyst. The reaction was carried out at reflux temperature of chloroform for 12 hours. After the reaction was completed, water was added three times with dichloromethane, and the solvent such as dichloromethane was removed by rotary evaporation.The crude product was obtained and purified further by silica gel column chromatography.Using petroleum ether/dichloromethane 1:1 (v/v) as an eluent, a blue-black solid (1.41 g, yield 88%) was obtained as the object compound M2.
The synthetic route of 2-(3-Oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile has been constantly updated, and we look forward to future research findings.