Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19472-74-3, name is 2-Bromophenylacetonitrile, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 19472-74-3
Step 1 : Nitrtle 19 (1.0 g, 5.10 mmol) was dissolved in DMF (20 mL) and was cooled to 0 C. NaH (60% in mineral oil, 449 mg, 11.22 mmol) was added and the reaction was warmed to 23 C and was stirred for 10 min. Dichloride {5, 1.3 g, 5.36 mmol) was added and the reaction was heated at 80 C overnight. The reaction was cooled to 23 C and was quenched with aqueous sat’d NH4CI (5 mL). The mixture was extracted with EtOAc (3x). The organic layers were washed with brine (1x), dried over MgS04, filtered and concentrated. The crude residue was recrystallized with EtOAc hexanes to obtain pure ferf-butyl 4-(2- bromophenyl)-4-cyanopiperidine-1-carboxylate as an off-white solid (20, 1.1 g, 59% yield). 1H NMR (400 MHz, CDCI3): delta 7.70-7.68 (m, 1 H), 7.39-7.37 (m, 2H), 7.25-7.21 (m, 2H), 4.31-4.27 (m, 2H), 3.29 (bt, 2H), 2.58-2.52 (m, 2H), 1.98 {td, 2H), 1.48 (s, 9H).
According to the analysis of related databases, 19472-74-3, the application of this compound in the production field has become more and more popular.