In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 151-18-8 as follows. Recommanded Product: 151-18-8
5 L of an aqueous solution containing 500 g of beta-aminopropionitrile (previously adjusted to pH 8.0 with concentrated hydrochloric acid) was added to a 10-L jacketed mechanically stirred glass reactor.Further, 250 g of a Nitrile hydrolyzing enzyme resting cell prepared by the method described in the patent CN 101701222B was added thereto, and fully suspended by mechanical stirring (250 rpm), and the temperature of the reaction vessel was controlled to 35 C by a constant temperature water bath, and the reaction time was 6 hours.The progress of the reaction was monitored by HPLC during this time.After the substrate was completely transformed, the reaction solution was heated to 90 C, incubated for 30 min, and the cells and denatured proteins were removed by filtration.The filtrate was concentrated and dried to give a mixture of beta-alanine and buffer salt as a solid, which contained 625 g of beta-aminopropionic acid in a yield of 98.4%.
According to the analysis of related databases, 151-18-8, the application of this compound in the production field has become more and more popular.