Related Products of 13388-75-5, The chemical industry reduces the impact on the environment during synthesis 13388-75-5, name is 2-(3,5-Dimethoxyphenyl)acetonitrile, I believe this compound will play a more active role in future production and life.
2-(3,5-dimethoxyphenyl)acetonitrile (100 g, 564 mmol, Eq: 1.00) was disolved in THF (500 mL). The solution was cooled to 0C and iodomethane (324 g, 142 mL, 2.26 mol, Eq: 4.0) was added. 1 M Potassium tert-butoxide solution in THF (1.69 L, 1.69 mol, Eq: 3) was added dropwise at 0C-2C over 60 min (conversion > 99% by GC after end addition). After 1 h at 0C, the reaction mixture was added to a stirred mixture of MTBE (1.5 L) and water (750 mL). The organic phase was separated, washed twice with 25% aqueous NaCl (750 mL), dried over Na2S04, filtered and concentrated under reduced pressure to give 115.8 g of the title compound as an oil (98.5a% by GC).
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