Month: April 2021

Synthetic Route of 621-50-1, A common heterocyclic compound, 621-50-1, name is 2-(3-Nitrophenyl)acetonitrile, molecular formula is C8H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of (3-nitro-phenyl)-acetonitrile (11.4 g, 70.4 mmol) in THF (100 ml) was heated to reflux and borane dimethylsulfide (2M in THF, 77.34 mmol) was added.The mixture was stirred for 2 h under reflux. After complete conversion the mix¬ ture was allowed to come to room temperature and a solution of HCI in ethanolM/45293 EPO (1 M) was added. After stirring the mixture for 30 min it was concentrated under reduced pressure. The residue was triturated with diethylether, filtered, washed with diethylether and dried in vacuo to give the product as a yellow powder (13.1 g, 92%).

The synthetic route of 621-50-1 has been constantly updated, and we look forward to future research findings.

Related Products of 35525-86-1, These common heterocyclic compound, 35525-86-1, name is 4-((Dimethylamino)methyl)benzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The reported procedure was applied with modification [42]. A solution of 4-(aminomethyl)benzonitrile (7), dissolved in tetrahydrofuran was added dropwise under a nitrogen atmosphere to a stirred suspension of LiAlH4 (4 eq) in tetrahydrofuran. The reaction mixture was stirred overnight at room temperature. The reaction was quenched by minimum amount of aqueous saturated sodium sulfate solution under a chilling temperature. The slurry mixture was filtered under vacuo and the residue washed with ethyl acetate. The combined filtrates dried over sodium sulfate, and evaporated in vacuo to afford oil or white solid products in 41-82% yields.

The synthetic route of 35525-86-1 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1572-52-7, name is 2-Methylenepentanedinitrile, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6H6N2

129 g (1 M) of N-(2-aminoethyl)imidazolidin-2-one and2 g of water are charged to a 500 cm3 reactor equipped with a mechanical stirrer, a jacket for heating, a dropping funnel and a system for rendering inert with nitrogen. The product is brought to 75-80 C. and then 116 g (1.1 M) of methyleneglutaronitrile are run in slowly. Reaction is allowed to take place, the reaction being monitored by potentiometric titration of the primary amines to given secondary amines. At the end of the reaction, the dinitrile is obtained with a yield of 89%. The product can be used as is.

According to the analysis of related databases, 1572-52-7, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1009-35-4, name is 4-Fluoro-3-nitrobenzonitrile, A new synthetic method of this compound is introduced below., Product Details of 1009-35-4

A mixture of 4-fluoro-3-nitrobenzonitrile (1 .0 g; 6.02 mmol), 0.502 ml (6.62 mmol) of 3- amino-propan-1 -ol and 1 .15 ml (6.62 mmol) of diisopropylethylamine in 5 ml THF is stirred at rt for 1 hr (temperature raises somewhat at the beginning). After concentration in vacuo the residue is dissolved in 50 ml of ethyl acetate, washed with 50 ml of 4percent aqueous sodium hydrogen carbonate and brine, dried and concentrated. 1 .32 g of pure title compound as a solid are thus obtained (99 percent yield).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10412-93-8, name is N-Benzyl-2-cyanoacetamide, A new synthetic method of this compound is introduced below., Recommanded Product: N-Benzyl-2-cyanoacetamide

General procedure: A mixture of 3-hydroxy-3-methylbutan-2-one 1 (10 mmol) and the substituted cyanoacetamides 2a-d (10 mmol) with a solution of sodium ethoxide (0.5 mmol) in ethanol (10 mL) was stirred at room temperature. After evaporation of the solvent, the residue was acidified with 6 M aqueous HCl. The mixture was neutralised with a solution of potassium carbonate (10%), then extracted with CH2Cl2 (3×25 mL). The combined organic layers were dried on MgSO4, filtered and concentrated in vacuum. The recovered solid was recrystallised in ethanol to provide compounds 3a-d.

The synthetic route of 10412-93-8 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6609-57-0, name is 2-Ethoxybenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Safety of 2-Ethoxybenzonitrile

NH4Cl (1.26 g, 23.52 mmoles) is introduced in a 100 ml round bottom flask and suspended in 16 ml of anhydrous toluene under argon atmosphere . The mixture is cooled in an ice bath and 2N Al (CH3) 3 (12 ml) in toluene are added dropwise, keeping under stirring for 30′ at room temperature. 2-Ethoxybenzonitrile (Ig) is added and the reaction is refluxed with stirring for 9 hours. Silica (0.8g) and then methanol (8 ml) are added to the mixture of reaction to eliminate the excess of Al (CH3) 3. The suspension is diluted with 8 ml of dichloromethane and then filtered washing the obtained solid several times with methanol .The filtered solution is acidified with cone. HCl and evaporated to dryness. The obtained residue is treated with 12 ml of a mixture of dichlorometane/methanol (9:1), filtered and the organic solution evaporated to dryness . The residue is washed with ether.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6609-57-0.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 92616-49-4, name is 4-Bromo-1-naphthonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C11H6BrN

Under N2 atmosphere, bis(pinacolato)diboron (8.4g, 33mmol), potassium acetate (6.5g, 66mmol) and [1,1?-bis(diphenylphosphine)ferrocene]palladium dichloride (1.2g, 1.76mmol) were respectively added to a solution of compound3-d (5.1g, 22mmol) in dioxane (150mL), the mixture was stirred at 80C for 6hrs. The mixture was evaporatedunder reduced pressure, the residue was filtered through celite, the filtrate cake was washed with dioxane (50mL), thefiltrate was evaporated under reduced pressure. The residue was purified with silica column chromatography (PE:EA =10:1) to give compound 3-c (6 g, yield 97%). LC-MS (ESI): m/z = 280 [M+H]+.

The synthetic route of 92616-49-4 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 1897-52-5, name is 2,6-Difluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1897-52-5, Safety of 2,6-Difluorobenzonitrile

Cyano-(2-cyano-3-fluoro-phenyl)-acetic acid ethyl ester. A mixture of cyanoacetic acid ethyl ester (26.7 mL, 251 mmol), 2,6- difiuorobenzonitrile (33.2 g, 239 mmol) and potassium carbonate (82.5 g, 597 mmol) in dimethyl sulfoxide (120 mL) was stirred at +55C for 16 hours and poured into ice- water mixture (ca. 400 mL). It was acidified with cone. aq. HCl with caution (CO2 evolution) and extracted with ethyl acetate (600 ml). The organic phase was washed with brine (100 mL) and evaporated to give 55.1 g of a pale yellow solid that was used in the next step without further purification. 1H NMR (500 MHz, CDCl3): 1.35 (t, J=7.0 Hz, 3H), 4.34 (m, 2H), 5.13 (s, IH), 7.33 (t, J=8.4 Hz, IH), 7.57 (d, J=7.9 Hz, IH), 7.33 (dd, J=7.9 Hz, J=13.9 Hz, IH).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,6-Difluorobenzonitrile, and friends who are interested can also refer to it.

6575-11-7, name is 2-Amino-6-chlorobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C7H5ClN2

To a mixture of 2-amino-6- chlorobenzonitrile (500 mg, 3.3 mmol), sodium azide (4.3 mmol, 1.3 eq.), and triethylamine hydrochloride (4.3 mmol, 1.3 eq.) in a sealed tube, 8 mL of toluene was added. The tube was tightly capped and the reaction was stirred and heated to 1000C overnight. The mixture was cooled to room temperature, diluted with another 10 mL of toluene, transferred to a separatory funnel and washed with water (3 X 20 mL). The aqueous extractions were combined and acidified to a peta of 4 with concentrated etaCI. EPO The solid was collected by filtration, washed with acetonitrile, and dried under vacuum to afford 137 mg of 3-chloro-2-(lH-tetrazol-5-yl)aniline. MS (EI) for C7H6ClN5: 196 (M+H).

The synthetic route of 6575-11-7 has been constantly updated, and we look forward to future research findings.

Reference of 103146-26-5, These common heterocyclic compound, 103146-26-5, name is 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile hydrobromide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The hydrobromide salt of racemic 4-[4-(dimethylamino)-1-(4′-fluorophenyl)-1-hydroxy-butyl]-3-(hydroxymethyl)-benzonitrile (50 g) was placed into a round bottom flask. Ethyl acetate (125 mL) was added and the mixture was stirred at 25-35 C. Aqueous sodium carbonate solution (19 g in 125 mL water) was added and the mixture was stirred at about 25-35 C. for 20 minutes. The layers were separated. The aqueous layer was extracted with ethyl acetate (125 mL). The organic layers were combined and washed with water (125 mL) followed by 10% sodium chloride solution (125 mL). The organic layer was evaporated under reduced pressure.

The synthetic route of 103146-26-5 has been constantly updated, and we look forward to future research findings.