262298-02-2, name is 4-Methoxy-2-methylphenylacetonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 4-Methoxy-2-methylphenylacetonitrile
Under anhydrous conditions, (4-methoxy-2-methylphenyl)acetonitrile(25.0 kg, 155 moles, available commercially) and 68.3 kg of ethyl acetate were mixed to obtain a solution. The resulting solution was heated to 35 C and potassium ^-butoxide in THF (100 kg, 20 wt %, 178 moles) was added over a 30 to 60 minute period controlling the temperature at 35 C. Following the addition, the reaction mass was heated to 45 C and held for 60 minutes. At the end of the hold period, a sample was analyzed by HPLC. The reaction mixture was then cooled to 25 C and combined with 3 other batches for a total of 843 kg of solution.
The synthetic route of 262298-02-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRISTOL-MYERS SQUIBB PHARMA COMPANY; WO2005/51954; (2005); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts