Electric Literature of 25978-68-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 25978-68-1 as follows.
To a solution of methyl 4-cyano-3-methylbenzoate (36 mg, 0.205 mmol) in 1,4-dioxane (0.5 mL) and water (0.500 mL), was added sodium hydrogen sulfide (0.019 mL, 0.616 mmol) and triethylamine hydrochloride (170 mg, 1.233 mmol). The reaction mixture was heated at 55 0C overnight. The reaction was allowed to cool and water was added. The mixture was extracted with EtOAc. The combined organic layers were dried (Na2SC^), filtered and the solvent was evaporated in vacuo to give the product as a yellow solid. LCMS calc. = 210.1; found = 210.2 (M+l)+. 1H NMR (500 MHz, CDCl3) 7.86 (s, 1 H); 7.84 (d, J = 8.1 Hz, 1 H); 7.42 (d, J= 7.9 Hz, 1 H); 7.16 (s, 2 H); 3.93 (s, 3 H); 2.51 (s, 3 H).
According to the analysis of related databases, 25978-68-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK & CO., INC.; WO2007/79186; (2007); A2;,
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