Application of 25978-68-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25978-68-1, name is Methyl 4-cyano-3-methylbenzoate belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A solution of 4-cyano-3-methyl-benzoic acid methyl esterfrom Example E2h.l (1.6g, 9.3mmol) in methanol (50ml) to 0C was treated with cobalt(II) chloride hexahydrate (5.1g, 18.6mmol). The mixture was stirred for 15min at room temperature then sodium borohydride (3.5g, 93mmol) was added portionwise. The reaction mixture was stirred for 90min then concentrated NH3 (5ml) was added drop-wise. The mixture was warmed up to room temperature over 30min, filtered through Celite filter agent, washed with methanol and the filtrate was concentrated in vacuo. The residue was purified by flash chromatography on silica gel (eluant; 1% 35% ammonia:10% methanol: 89% dichloromethane) to yield the title compound (670mg, 37%) .
The synthetic route of Methyl 4-cyano-3-methylbenzoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; FERRING B.V.; WO2006/21213; (2006); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts