Application of 53005-44-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 53005-44-0, name is 2-Methoxy-6-methylbenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.
Intermediate 146 1-(2-methoxy-6-methylphenyl)-2-phenylethanone: To intermediate 145 (5.0 g, 34.03 mmol) in THF (50 ml), benzylmagnesium chloride (34 ml, 2M in THF, 68.02 mmol) was added at 0 C. over 30 min and heated to reflux for 15 h. The reaction mixture was cooled to room temperature, 2N HCl (200 ml) was added and again refluxed for 4 h. The reaction mixture was cooled and extracted with ethyl acetate, dried over sodium sulphate and concentrated. The crude product was column chromatographed with ethyl acetate:petroleum ether to afford to afford the title compound as brown liquid (3.7 g, 45%). 1H-NMR (delta ppm, CDCl3, 400 MHz): 7.30-7.18 (m, 6H), 6.76 (m, 2H), 4.07 (s, 2H), 3.83 (s, 3H), 2.02 (s, 3H).
The chemical industry reduces the impact on the environment during synthesis 2-Methoxy-6-methylbenzonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Rhizen Pharmaceuticals SA; US2012/289496; (2012); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts