10444-38-9, name is Ethyl 4-cyanobutanoate, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C7H11NO2
General procedure: A 1 M solution of LiHMDS in THF (5.1 eq) was added slowly to a solution of NH2OBn.HCl (1.1 eq.) in THF (4 mL/mmol) at -78C. The mixture was stirred 30 min before the addition of the nitrile (1 eq). After total consumption of the starting materials (TLC), the reaction was quenched with a saturated aqueous solution of NH4Cl, warmed up to room temperature, and extracted three times with AcOEt. The collected organic layers were dried over Na2SO4, filtered and evaporated to dryness under reduced pressure.
The synthetic route of 10444-38-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Nguyen-Trung, Anh Thu; Tritsch, Denis; Grosdemange-Billiard, Catherine; Rohmer, Michel; Bioorganic and Medicinal Chemistry Letters; vol. 23; 6; (2013); p. 1643 – 1647;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts