Adding a certain compound to certain chemical reactions, such as: 4421-09-4, name is 3,4-(Methylenedioxy)benzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4421-09-4, Computed Properties of C8H5NO2
5-(1,3-benzodioxol-5-yl)-1H-tetrazole was synthesized from 1,3-benzodioxole-5-carbonitrile by following a reported procedure [46]. The requisite nitrile (2) was prepared from Piperonal (1,3-benzodioxole-5-carbaldehyde) via oxime formation, followed by dehydration with acetic anhydride, following a reported procedure [45]. Nitrile (2.95 g, 20 mmol), sodium azide (1.43 g, 22 mmol) and zinc bromide (4.50 g, 20 mmol), were put in 60 mL of water. 5 mL of isopropanol was also added to stop the formation of clumps. The reaction mixture was refluxed for 24 h and monitored by TLC; vigorous stirring is essential. After 24 h HCl (3 N, 30 mL) and ethyl acetate (100 mL) were added, and vigorous stirring was continued until no solid was present and the aqueous layer had a pH of 1. If necessary, additional ethyl acetate was added. The organic layer was isolated and the aqueous layer extracted with 2 × 100 mL of ethyl acetate. The combined organic layers were evaporated, 200 mL of 0.25 N NaOH was added, and the mixture was stirred for 30 min, until the original precipitate was dissolved and a suspension of zinc hydroxide was formed. The suspension was filtered, and the solid washed with 20 mL of 1 N NaOH. To the filtrate was added 50 mL of 3 N HCl with vigorous stirring causing the tetrazole to precipitate. The tetrazole was filtered and washed with 2 × 50 mL of 3 N HCl and dried in a drying oven to furnish the tetrazole as a white powder.
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Reference:
Article; Wani, Mohmmad Younus; Bhat, Abdul Roouf; Azam, Amir; Choi, Inho; Athar, Fareeda; European Journal of Medicinal Chemistry; vol. 48; (2012); p. 313 – 320;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts