Adding a certain compound to certain chemical reactions, such as: 21423-84-7, name is 2-Chloro-4-methylbenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 21423-84-7, Recommanded Product: 21423-84-7
To a solution of 2-chloro-4-methylbenzonitrile (0.50 g, 3.31 mmol) in anhydrous THF (7 mL) at 0 C was added 1 M solution of phenyl magnesium bromide in THF (4.96 mL, 4.96 mmol) over 10 minutes and the resulting mixture was warmed to rt. The reaction mixture was stirred at rt for 30 minutes followed by heating to 60 C and stirred at the same temperature for 2 h. After completion of the i mine formation, the reaction mixture was cooled to 0 C and methanol (10 mL) was added very slowly followed by sodium borohydride (0.188 g, 4.96 mmol). The resulting mixture was warmed to rt and stirred overnight After completion of the reaction, solvent was removed under vacuum and water (20 mL) was added into the reaction mixture and extracted with ethyl acetate (2 x 35 mL). The combined organic layers were dried over Na2SO4 and concentrated. The product was purified by silica gel column chromatography (10% ethyl acetate/Hexanes) to provide title compound (0.16 g, 21 %), 1H NMR (400 MHz, DMSO-d6) delta ppm 7.59-7.61 (d, 1H), 7.24-7.32 (m, 4H), 7.15-7.19 (q, 3H), 5.37 (s, 1H), 2.31-2.34 (t, 1H), 2.26 (s, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-4-methylbenzonitrile, and friends who are interested can also refer to it.
Reference:
Patent; TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; WO2013/19621; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts