50397-74-5, name is 4-Amino-3-bromobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 4-Amino-3-bromobenzonitrile
50.0 g (253.76 mmol) of 4-amino-3-bromobenzonitrile, 4-bromobenzoyl chloride 55.7 g (253.76 mmol) of (4-bromobenzoyl chloride) and 500 mL of pyridine were added thereto, followed by stirring at reflux for at least 12 hours. After the reaction was completed, the solvent was distilled off under reduced pressure. Solid to pale yellow by solidification with diisopropyl ether (IPE) 75.6 g (yield: 78.3%) of a mixture (intermediate (12)) was obtained.
The synthetic route of 50397-74-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Raepto Co., Ltd.; Seok Mun-gi; Go Byeong-su; Im Cheol-su; Kim Hyeon-a; Kim Gyu-sik; Park Yong-pil; Han Gap-jong; Oh Yu-jin; (37 pag.)KR102059550; (2019); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts