Electric Literature of 50397-74-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 50397-74-5 name is 4-Amino-3-bromobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
An ethanolic solution (5 mL) of 4-amino-3-bromobenzonitrile (L3, 1 mmol, 0.197 g) was added to ethanolicsolution (5 mL) of AgNO3 (0.6 mmol, 0.1 g). The test tube was covered with a perforated foil. Afterkeeping the solution in air for 4 days, light yellow crystals of 3 suitable for structure determinationwere obtained. Yield 80%, m.p. 130-132 C. Anal. Calcd for C21H15AgBr3N7O3: C, 33.15; H, 1.99; N, 12.88%. Found: C, 33.14; H, 1.97; N, 12.89%. IR (KBr, cm-1): 3481 (m), 3360 (s), 3215 (w), 2628 (w), 2221 (s), 1769(w), 1633 (s), 1594 (m), 1507 (s), 1388 (s). 1H NMR (400 MHz, DMSO) delta/ppm: 7.83 (d, J = 1.9 Hz, 1H), 7.45(dd, J = 8.5, 1.9 Hz, 1H), 6.82 (d, J = 8.5 Hz, 1H), 6.37 (s, 2H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Amino-3-bromobenzonitrile, and friends who are interested can also refer to it.
Reference:
Article; Qian, Wei; Yuan, Hao-Kun; Zhang, Ran; Fang, Rui-Qin; Journal of Coordination Chemistry; vol. 69; 23; (2016); p. 3593 – 3602;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts