Reference of 6136-93-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6136-93-2 as follows.
(iii) 2.2-Diethoxyethanethioamide(See, for example, Inami, K., Shiba, T., Bull. Chem. Soc. Jpn., 1985, 58, 352.) Diethoxyacetonitrile (0.050 g, 0.5 mmol; see step (ii) above) was placed in a 10 mL microwavable vial, methanol (5 mL) and (NEU)2S (54 muL, 0.5 mmol (40% wt solution in water)) was then added. The vial was then heated to 8O0C at IOOW for 15 min and the reaction then allowed to cool to RT. The solvent was then removed under reduced pressure and the residue dissolved in ethyl acetate (15 mL) and extracted with water (2 x 10 mL) and brine (2 x 5 mL). The organic layer was then dried (MgSO4), filtered and concentrated under reduced pressure to yield the sub-title compound as a white/off- white solid (0.081 g, 99%). m.p. = 92-94C. V1113x KBr/cm”1: 3335, 3171 upsilon(N-H), 2976, 2885 upsilon(C-H), 2247 upsilon(N?C), 1645, 1449 upsilon(C=S), 1019 delta(C-O). deltaH 1H(CDCl3): 1.26 (6H5 1, 2(CH3) (J=8.0Hz)), 3.71 (4H, m, 2(CH2)), 5.05 (IH, s, C-H), 7.70 (2H, d, N-H).
According to the analysis of related databases, 6136-93-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; UNIVERSITY OF STRATHCLYDE; WO2008/38018; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts