Month: May 2021

Application of 56043-01-7, A common heterocyclic compound, 56043-01-7, name is 2-Amino-6-methylbenzonitrile, molecular formula is C8H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-amino-6-methylbenzonitrile (132.2 mg, 1.0 mmol) was sequentially added to a 100 mL high pressure sealed tube, benzyl alcohol(129.6mg, 1.2mmol, 1.2equiv.), cesium hydroxide monohydrate (167.9mg, 1.0mmol), add an air ball at the sealing mouthAfter stirring at 120 C for 36 h, the product was completely purified by column chromatography by TLC or GC-MS. The isolated yield was 51%.

The synthetic route of 56043-01-7 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 218632-01-0,Some common heterocyclic compound, 218632-01-0, name is 3-Fluoro-4-nitrobenzonitrile, molecular formula is C7H3FN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 3-Fluoro-4-nitrobenzonitrile (1.0 g, 6.0 mmol) in DMA (5 inL) were added Beta-Alanine ethyl ester HCl (1.4 g, 9.03 mmol) and DIPEA (1.6 mL, 9.03 mmol). The reaction mixture was stirred at room temperature for 16 h (the recation was completed; the reaction mixture turned to orange from yellow in color). The reaction mixture was then diluted with ethyl acetate and washed with water (x4). The organic phase was then dried over Na2SO4 and concentrated to afford 1.53 g (96%) of the desired product as yellow solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Fluoro-4-nitrobenzonitrile, its application will become more common.

Related Products of 90401-84-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 90401-84-6, name is 6-Cyano-1-tetralone belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step 3: 6-Bromo-5-oxo-5,6,7,8-tetrahydronaphthalene-2-carbonitrile Bromine (0.8 mL, 15.7 mmol) was added to a solution of 5-oxo-5,6,7,8-tetrahydro-naphthalene-2-carbonitrile (2.7 g, 15.7 mmol), prepared in the previous step, in dry methylene chloride (55 mL) at 0 C. The reaction was warmed to room temperature. After 2 h, the reaction was diluted with methylene chloride and washed with 5% sodium thiosulfate and brine. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to give 4.3 g of crude product. Purification of the crude product on silica gel using 10% ethyl acetate:hexane as the eluent gave 6-bromo-5-oxo-5,6,7,8-tetrahydronaphthalene-2-carbonitrile (3.2 g, 81%), MS (ES) m/z 251 [M+H]+.

The synthetic route of 6-Cyano-1-tetralone has been constantly updated, and we look forward to future research findings.

Electric Literature of 15996-76-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15996-76-6, name is 4-(Aminomethyl)benzonitrile hydrochloride belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Intermediate 28: tert-butyl {4-[amino(hvdroxyirnino)methyllbenzyl}carbamateStep 1: tert-butyl 4-cyanobenzylcarbamate To a solution of 4-cyanobenzylamine hydrochloride (1.05 g; 6.25 mmol) in water (10 mL) was added sodium hydroxide (0.75 g; 18.75 mmol) and di-tert-butyldicarbonate (1 .49 g; 6.87 mmol) and the mixture was stirred for 16 hours. The solid was collected by filtration and dried in a vacuum oven at 40C for 48 hours. The title compound was isolated as a white solid (1 .35 g; 80%). 1H NMR: (CDCI3, 400MHz) delta 7.62 (2H, d, J = 8.1 Hz), 7.39 (2H, d, J = 8.0 Hz), 4.97 (1 H, s), 4.37 (2H, d, J = 6.2 Hz), 1.46 (9H, s).

The synthetic route of 4-(Aminomethyl)benzonitrile hydrochloride has been constantly updated, and we look forward to future research findings.

Electric Literature of 25808-30-4, These common heterocyclic compound, 25808-30-4, name is 2-(Methylamino)acetonitrile hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A dry one neck 50mL round bottom flask equipped with magnetic stirring, reflux condenser, and nitrogen atmosphere (or drying tube) was charged with the vinamidinium salt (3.30 mmol), methylaminoacetonitrile hydrochloride (0.355 g, 3.33mmol) and triethylamine (0.97 mL, 6.95 mmol).Anhydrous acetonitrile (10 mL) was added and the mixture was allowed to stir at reflux overnight. The flask wascooled to room temperature and the volatiles were removed in vacuo. The remainingsolid was partitioned between water and ethyl acetate. The ethyl acetate layer was dried over sodiumsulfate and concentrated in vacuo togive the crude solid.

Statistics shows that 2-(Methylamino)acetonitrile hydrochloride is playing an increasingly important role. we look forward to future research findings about 25808-30-4.

Reference of 179898-34-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 179898-34-1, name is 3-Bromo-5-fluorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(i) 3-bromo~5-methoxybenzonitrileSodium methoxide (2.02 g) was added to a stirred solution of 3-fluoro-5-bromobenzonitile (5.0 g) in DMPU (20 ml) and stirred at RT for 2 h. The reaction was diluted with water and the resulting solid formed was filtered and washed with water, then dried in vacuo to give the subtitle compound (5.10 g). lH NMR DMSO-d6: delta 7.39-7.38 (IH, s), 7.30-7.26 (IH, m), 7.11 (IH, s), 3.83 (3H, s).

The synthetic route of 3-Bromo-5-fluorobenzonitrile has been constantly updated, and we look forward to future research findings.

Synthetic Route of 1220630-83-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1220630-83-0 name is 3-Amino-4-(trifluoromethyl)benzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(b) tert-Butyl N-[5-cyano-2-(trifluoromethyl)phenyl1-carbamateA mixture of 3-amino-4-(trifluoromethyl)benzonitrile (10.0 g; 53.7 mmol), DCM (100 ml.) and TEA (8.2 ml 59 mmol) was treated dropwise with a solution of BOC2O (12.9 g; 59.1 mmol) in DCM (50 ml.) at 00C and thereafter stirred over night. Another portion of BoC2O in DCM and DMAP (656 mg; 5.37 mmol) was added and the mixture was stirred for another 12 h at rt, washed with water and brine, dried over Na2SO4, filtered and concentrated. The residue was purified by column chromatography to give the sub-title compound. Yield: 8.50 g (55%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Amino-4-(trifluoromethyl)benzonitrile, and friends who are interested can also refer to it.

Related Products of 10412-93-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10412-93-8 name is N-Benzyl-2-cyanoacetamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Under N2 atmosphere, t-BuOK (246 mg, 2.2 mmol) and various acetamides 2 (1.0 mmol) in dry THF (5 mL) were placed in a 10 mL Schlenk flask at -78 C. The suspension was warmed to room temperature for 30 min and recooled to -78 C. (Z)-methyl-bromo-4,4,4-trifluorobut-2-enoate 1 (117 mg, 0.5 mmol) was added at this temperature. The solution was stirred at this temperature until the reaction was completed (usually 15-30 min), followed by adding saturated aqueous NH4Cl solution (10 mL). The solution mixture was extracted with EtOAc (3×10 mL), and the combined organic layer was washed with brine, then, dried over Na2SO4. After removal of solvents under vacuum, the crude product was further purified by silica gel column chromatography (PE:EA = 1:2 v/v) to afford pure product 4.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, N-Benzyl-2-cyanoacetamide, and friends who are interested can also refer to it.

Application of 3215-64-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3215-64-3, name is 2-(2,6-Dichlorophenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows.

5.47 g of 60% NaH are added, in 5 minutes, to 21 g of the aldehyde obtained in the previous stage, dissolved in 240 ml of DMF and cooled to 5 C., followed by 29.05 g of 2,6-dichlorophenylacetonitrile, in 20 minutes, in small fractions. The stirring is continued for 30 minutes at 5 C. and then at ambient temperature overnight. The reaction medium is cooled to 5 C. and 65 ml of a saturated NH4Cl solution and then 500 ml of a water/ice mixture are added; a red precipitate forms, which is filtered off, washed twice with water, filter-dried to a maximum, and washed with ether, with 100 ml of chloroform and then with ether again; after drying, a beige solid is obtained, Mp=250-253 C., m=29.92 g.

The chemical industry reduces the impact on the environment during synthesis 2-(2,6-Dichlorophenyl)acetonitrile. I believe this compound will play a more active role in future production and life.

Adding a certain compound to certain chemical reactions, such as: 2941-29-9, name is Cyclopentanone-2-carbonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2941-29-9, Product Details of 2941-29-9

Cyclopentanone-2-carbonitrile (4.00 g, 36.65 mmol), methylhydrazine (2.12 mL, 40.32mmol) and TEA (7.07 mL, 50.89 mmol) in toluene (26.76 mL) were heated to 120 °C for16 hours. The reaction was cooled down to room temperature and the solvent wasevaporated. The residue was taken up into Et20, filtered and dried under vacuo. The filtrate was evaporated and the crude residue was purified via silica gel chromatography(Stationary phase: Irregular SiOH 20-45 jim, 450 g, mobile phase gradient: from 44percentHeptane, 6percent MeOH (+ 10percent NH4OH), 50percent EtOAc to 42percent Heptane, 8percent MeOH (+ 10percentNH4OH), 50percent EtOAc). The pure fractions were collected and evaporated to give 205 mg of intermediate 18b (4percent yield) and 545 mg of intermediate 19b (11percent yield).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.