Month: May 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 654-70-6, name is 4-Cyano-3-trifluoromethylaniline, This compound has unique chemical properties. The synthetic route is as follows., name: 4-Cyano-3-trifluoromethylaniline

Thionyl chloride (46.02 g, 0.39 mol) was added dropwise to a cooled solution (less than 4 C.) of (R)-3-bromo-2-hydroxy-2-methylpropanoic acid (51.13 g, 0.28 mol) in 300 mL of THF under an argon atmosphere. The resulting mixture was stirred for 3 h under the same condition. To this was added Et3N (39.14 g, 0.39 mol) and stirred for 20 min under the same condition. After 20 min, 5-amino-2-cyanobenzotrifluoride (40.0 g, 0.21 mol), 400 mL of THF were added and then the mixture was allowed to stir overnight at RT. The solvent was removed under reduced pressure to give a solid which was treated with 300 mL of H2O, extracted with EtOAc (2*400 mL). The combined organic extracts were washed with saturated NaHCO3 solution (2*300 mL) and brine (300 mL). The organic layer was dried over MgSO4 and concentrated under reduced pressure to give a solid which was purified from column chromatography using CH2Cl2/EtOAc (80:20) to give a solid. This solid was recrystallized fromCH2Cl2/hexane to give 55.8 g (73.9%) of (2R)-3-bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide as a light-yellow solid.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 654-70-6.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 50397-74-5, name is 4-Amino-3-bromobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Formula: C7H5BrN2

Remarkably, the unprotected amine function in 4-amino-3-bromobenzonitrile (5c) is well tolerated in the one-pot coupling procedure and the biphenyl 6d was isolated in 79 % yield.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 50397-74-5.

Electric Literature of 76469-88-0, A common heterocyclic compound, 76469-88-0, name is Methyl 4-(cyanomethyl)benzoate, molecular formula is C10H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of methyl iodide (5.35ml) and methyl 4-(cyanomethyl)benzoate (5g) in THF (25ml) was added slowly to a solution of potassium tert-butoxide (8 g) in THF (25ml) at -30 C in an inert atmosphere. The reaction mixture was stirred at RT for about 2 hours. It was then quenched with water (10 ml) and EtOAc was added. The organic and aqueous layers were separated. Organic layer was washed successively with water, brine and dried over sodium sulfate. Organic solvent was concentrated to obtain violet residue which was purified by silica gel column chromatography using 20 % EtOAc – Petroleum ether to obtain off white solid. The off white solid was crystallized in chloroform – petroleum ether to obtain title compound as white solid. *HNMR (CDC13; 300MHz): delta 8.06 (d, 2H), 7.58 (d, 2H), 3.97 (s, 3H), 1.76 (s, 6H); MS (ESI) m/z 204.1 [M+H]+.

The synthetic route of 76469-88-0 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 154607-01-9, name is 4-Bromo-2-chlorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 154607-01-9, name: 4-Bromo-2-chlorobenzonitrile

A mixture of .4-bromo-2-chlorobenzonitrile (1.082 g, 5 mmol), 5-(4,4,5,5-tetramethyl- 1.3,2«dtoxaborolan-2-yl)mcotinaldehyde (1.165 g, 5.00 mmol), Pd(PPh3J4 (0.144 g. 0.125 mmol), sodium carbonate (2.5 ml, 5.00 mmo.) in 1,4-dioxane (20 mL) was heated to reflux for 6 h. After cooling to room temperature, the solid was filtered and washed by ethyl acetate and water. After drying under vacurnn, yellow powder was collected (1 g). 1H NMR (400 MHz. CDCI3): S 7.63 (dd, J = 1.68, 8 Hz, 1H)1 7.79 (d, J * 1.68 Hz, 1H), 7.83 (d, J » 8 Hz, 1H)1 8.35 (dd, J = 2.24 Hz, 2.04 Hz. 1H)1 9.07 (d, J * 2.36 Hz, 1H), 9.15 (d, J = 1.88 Hz. 1H)1 10.22 (s, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3598-13-8, name is 2-(4-Chlorophenoxy)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows., category: nitriles-buliding-blocks

To a solution of potassium tert-butoxide (1.72 g, 15.4 mmol) in DMF (15 ml) cooled at 30 C., was added dropwise a solution of 2-fluoro-4-nitro-benzyloxybenzene (1.73 g, 7 mmol) and 4-chlorophenoxyacetonitrile (1.29 g, 7.7 mmol) while maintaining the temperature below -25 C. After completion of addition, the mixture was stirred for 30 minutes at -20 C. and then poured onto a mixture of cold 1N hydrochloric acid and ether. The organic layer was separated, washed with 1N sodium hydroxide, followed by water, brine, dried (MgSO4). The volatiles were removed under vacuum and the residue was purified by column chromatography eluding with methylene chloride/petroleum ether (3/1) to give a mixture of 3-cyanomethyl-2-fluoro-4-nitrobenzyloxybenzene and 5-cyanomethyl-2-fluoro-4-nitrobenzyloxybenzene (1.2 g, 60%). 1H NMR Spectrum: (DMSOd6) 4.22 (s, 2H, 3-cyanomethyl isomer); 4.3 (s, 2H, 5-cyanomethyl isomer); 5.32 (s, 2H, 5-cyanomethyl isomer); 5.36 (s, 2H, 3-cyanomethyl isomer); 7.3-7.7 (m, 6H); 8.1 (d, 1H, 3-cyanomethyl isomer); 8.2 (d, 1H, 5-cyanomethyl isomer)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3598-13-8.

Adding a certain compound to certain chemical reactions, such as: 3598-14-9, name is Phenoxyacetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3598-14-9, name: Phenoxyacetonitrile

A mixture of 1 g of phenoxyacetonitrile, 2.4 g of K2CO3 and 1.2 g of hydroxylamine hydrochloride in 60 ml of EtOH and 10 ml of water is heated at reflux for 3 hours. The reaction mixture is concentrated under vacuum and the residue is taken up in water and extracted with AcOEt. The organic phase is extracted with 1N HCl solution, the aqueous phase is alkalified by adding 1N NaOH solution, extracted with AcOEt and dried over MgSO4, and the solvent is evaporated under vacuum. This gives 0.9 g of the expected compound in the form of a colourless oil which crystallizes. 1H NMR: CDCl3 (300 MHz): delta (ppm): 4.56: s: 2H; 4.90: s: 2H; 6.95-7.02: m: 3H; 7.26-7.32: m: 2H.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Phenoxyacetonitrile, other downstream synthetic routes, hurry up and to see.

Reference of 58633-04-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 58633-04-8 name is 4-Amino-3,5-dibromobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a suspension of 4-amino-3,5-dibromobenzonitrile (11 g, 40 mmol) in toluene (80 ml) was added thiophosgene (5.06 g, 44 mmol, 1.1 eq.). The reaction mixture was stirred under reflux for 16 h. After cooling to RT, the volatile material was removed in-vacuo, residue was suspended in dioxane (80 mL) and treated with ammonium (27 w/w %, 9.85 g) with stirring at room temperature After for 30 min., dioxane was removed in-vacuo. The solid obtained was washed with ether (50 mL), water (50 mL) and ether (50 mL), dried in vacuo to provide 9.6 g (70% yield) of the title compound (2). 1H-NMR-(400 MHz, CDCl3)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Amino-3,5-dibromobenzonitrile, and friends who are interested can also refer to it.

Synthetic Route of 5414-21-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5414-21-1, name is 5-Bromovaleronitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 5-bromovaleronitrile (5.12 g, 30.0 mmol) in DMF (40 mL) was added potassium phthalimide (6.00 g, 32.4 mmol). The above suspension was heated at 60 oC for 16 h, concentrated, and partitioned between H20 and DCM. The DCM layer was separated, washed with HA0 (3x) and brine, dried over NA2S04, and concentrated to give the title compound (6.84 g, quantitative yield) as a white solid. 1H NMR (CDC13) : delta 7.87-7. 80 (m, 2H), 7.76-7. 70 (m, 2H), 3.73 (t, 2H, J= 6. 1HZ), 2.43 (t, 2H, J= 7.1 Hz), 1.89-1. 82 (m, 2H), 1.74-1. 67 (m, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromovaleronitrile, other downstream synthetic routes, hurry up and to see.

76469-88-0, name is Methyl 4-(cyanomethyl)benzoate, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: Methyl 4-(cyanomethyl)benzoate

j00372j To a solution of product from Step 2 (200 mg, 0.695 mmol) in methanol (30 mL) were added methyl 4-(cyanomethyl)benzoate (0.83 4 mmol) and NaOH (1.39 mmol). The resulting mixture was stirred at 50C for 4h. After the reaction mixture was cooled, it was diluted with THF (20 mL) then stirred at room temperature for 10 minutes. The solids were isolated by filtration to provide the title compound (202 mg, 65%) as a yellow solid. LCMS [M+H]: 444.9.

The synthetic route of 76469-88-0 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 1020252-22-5, name is 2-(((2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1020252-22-5, Formula: C14H12N2O4

c) 4-OXO-L, 4-DIHYDROQUI2OLINE-8-CARBONITRILE 2-{[(2,2-Dimethyl-4,6-dioxo-1, 3-dioxan-5-ylidene) methyl] amino} benzonitrile (4 g) was added portionwise to REFLUXING DIPHENYLETHER (40 mL). The reaction was refluxed for a further 5 min and then cooled to room temperature. The reaction mixture was poured into isohexane (100 mL) with vigorous stirring. The resulting yellow supernatant and the isohexane layer were decanted from the brown oily residue which was allowed to solidify at room temperature to afford the titled compound (2.1 g). 1H NMR (400 MHz, d6-DMSO) 8 11.79 (1H, s), 8.39 (1H, d), 8. 22 (1H, d), 7.86 (1H, t), 7.46 (1H, t), 6.18 (1 H, d).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(((2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzonitrile, other downstream synthetic routes, hurry up and to see.