Month: May 2021

Adding a certain compound to certain chemical reactions, such as: 628-20-6, name is 4-Chlorobutyronitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 628-20-6, category: nitriles-buliding-blocks

A solution of 4-chlorobutyronitrile (2.5 mmol) in dimethylformamide (1 mL) was added during 1.5h to a mixture of the arylamine (2.5 mmol), Cs2CO3 (2.5 mmol) and KI (5 mmol) in dimethylformamide (4 mL). The mixture was stirred at the indicated temperature and time. After completion of the reaction, as indicated by TLC, the mixture was treated with ethyl ether (50 mL) and water (10 mL). The aqueous phase was separated and extracted with ethyl ether (30 mL). The combined organic layers were dried over anhydrous sodium sulphate and filtered. The solvent was evaporated in vacuo. The crude product was purified by column chromatography (Silica gel, hexane:DCM).

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Synthetic Route of 124289-21-0,Some common heterocyclic compound, 124289-21-0, name is 3-Bromo-5-methylbenzonitrile, molecular formula is C8H6BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 1 -(4-(3,4-dichlorophenyl)-5-(isopropylthio)thiazol-2-yl)-5- (methoxycarbonyl)-3-methyl-1H-pyrazol-4-ylboronic acid (50 mg, 0.10 mmol), , 3-bromo-5- methylbenzonitrile (24 mg, 0.12 mmol), Pd(PPh3)4 (12 mg, 0.10 mmol), Na2003 (54 mg, 0.51 mmol) in degassed 1,4-dioxane and H20 (4:1, 2.1 mL) was heated at 85 C for 18 hours. Water (5 mL) was added and the mixture was extracted with EtOAc (3x5mL). The combined organic layers were dried with sodium sulfate, filtered and evaporated under reduced pressure. The crude product was purified by flash chromatography on silica gel using a solution of ethyl acetate in hexanes (2 to 5%) and afforded the title compound (22 mg, 0.039 mmol, 38%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Bromo-5-methylbenzonitrile, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19619-22-8, name is 4-Aminoisophthalonitrile, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H5N3

4-amino-3-[5-(4-methylpiperazinyl)benzimidazol-2-yl]-2-oxohydroquinoline-6-carbonitrile 4-Amino-isophthalonitrile and ethyl 2-[5-(4-methylpiperazinyl) benzimidazol-2-yl]acetate were reacted according to Example 46. LC/MS m/z 400.1 (MH+), Rt 1.54 minutes.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 134450-56-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 134450-56-9 as follows.

Under nitrogen atmosphere, 16.2 g of the intermediate (D), 4.92 g of 4.5-difluorophthalonitrile, 9.12 g ofpotassium carbonate, 120 mL of N-methyl-2-pyrrolidinone were put into a flask and stirred at the room temperature for 10 hours. Water was added to the reaction solution. The obtained solution was filtered to obtain a deposited solid. The obtained deposited solid was washed with toluene, whereby 3.25 g (yield 17%) of a yellow solid of the compound 4 was obtained.

According to the analysis of related databases, 134450-56-9, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51762-67-5, name is 3-Nitrophthalonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 3-Nitrophthalonitrile

2-(3,4-Dimethoxyphenyl)ethanol (2.10?g, 11.56?mmol) was stirred in dry DMSO in the presence of finely ground anhydrous K2CO3 (?2.00?g, excess). After stirring for 30?min under an N2 atmosphere, 3-nitrophthalonitrile (2.00?g, 11.56?mmol) was added to this mixture dropwise. The reaction mixture was monitored by TLC (CHCl3) for 3?days at ca. 50?C. The mixture was then cooled to ambient temperature and poured into ca. 250?mL ice-water. After completion of the precipitation, the solid product was filtered and purified by column chromatography using a mixture of CHCl3:MeOH (2:1 v/v) as the eluent. The obtained products are excellently soluble in CHCl3, THF, DMF and DMSO. Yield of 2: 0.69?g (78%), m.p.: 138?C. Anal. Calc. for C18H16N2O3 (308.33?g/mol): C, 70.12; H, 5.23; N, 9.09. Found: C, 70.09; H, 5.20; N, 9.05%. FT-IR (thin film) nu/cm-1: 3094, 2968, 2832, 2241, 1608, 1582, 1530, 1464, 1405, 1378, 1269, 1159, 1033, 960, 813, 459. 1H NMR ([d6]-DMSO) delta, ppm: 8.10, 7.80, 7.62, 6.85, 6.80, 6.65, 4.40, 3.80, 3.00. 13C NMR ([d6]-DMSO) delta, ppm: 161.5, 149.1, 148.1, 137.1, 130.7, 121.3, 119.1, 116.4, 116.0, 113.6, 113.4, 112.4, 71.1, 63.1, 56.1, 55.9, 34.8.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 115279-57-7, name is 2-(4-Aminophenyl)-2-methylpropanenitrile, A new synthetic method of this compound is introduced below., category: nitriles-buliding-blocks

Example 1f 2-[4-(6-Bromo-3-nitro-quinolin-4-ylamino)-phenyl]-2-methyl-propionitrile 18 g (62.6 mmol) of 6-bromo-4-chloro-3-nitro-quinoline (Example 1c) and 11 g (68.9 mmol) of (2-(4-amino-phenyl)-2-methyl-propionitrile (Example 1e) are dissolved in 350 ml of acetic acid and stirred for 2 h. After this time, water is added and the yellow precipitate is filtered off and washed with H2O. The solid is dissolved in EtOAc-THF (1:1), washed with sat. aqueous NaHCO3 and dried over MgSO4. The organic phase is evaporated to dryness to give the title compound as a yellow solid. ES-MS: 411, 413 (M+H)+, Br pattern; analytical HPLC: tret=3.69 min (Grad 1).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1187-42-4 as follows. HPLC of Formula: C4H4N4

General procedure: To a mixture of 2,3-diaminomaleonitrile (1 mmol) and corresponding aromatic aldehyde (1 mmol) in H2O (5 mL), cerium (IV) ammonium nitrate (5 molpercent) was added and the reaction mixture stirred at room temperature for the desired time, as shown in Table 3. After completion of the reaction (reaction progress was monitored by TLC, ethyl acetate/n-hexane, 3:1), cold water (5?10 mL) was addedand the solid was filtered and washed with cold water/ethanol and air-dried to give the Schiff base product.

According to the analysis of related databases, 1187-42-4, the application of this compound in the production field has become more and more popular.

Electric Literature of 53312-81-5,Some common heterocyclic compound, 53312-81-5, name is 5-Amino-2-fluorobenzonitrile, molecular formula is C7H5FN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 2: 2-Fluoro-5-[5-(3-morpholin-4-ylphenoxy)-pyrimidin-2-ylamino]- benzo-nitrile A suspension of 4-[3-(2-chloro-pyrimidin-5-yloxy)phenyl]morpholine (150 mg, 0.515 mmol), 5-amino-2-fluorobenzonitrile (70.2mg, 0.515mmol), in’5′(dibenzylideneacetone)-palladium(0) (23.6mg, 0.025mmol), 4,5- bi5′(diphenylphosphino)-9,9- dimethylxanthene (30mg, 0.0515mmol) and cesium carbonate (336mg, 1.03mmol) in degassed 1,4-dioxane (4mL) was heated at 80C for 2 days. The suspension was diluted with ethyl acetate and washed with water and brine. The organic phase was dried (MgS04) and the solvent removed under reduced pressure. The crude product was purified by column chromatography on silica (ethyl acetate:hexane 1: 1) to afford 2-fluoro-5-[5-(3-morpholin-4-ylphenoxy)pyrimidin-2- ylamino]benzonitrile as a light yellow solid (70mg, 35%).Mass: (ES+) 392 (M+H)+ HPLC: 97%NMR: 5H (d6-DMSO) 3.08 (4H, m), 3.69 (4H, m), 6.39 (1H, dd), 6.61 (1H, br s), 6.70 (1H, dd), 7.18 (1H, t), 7.47 (1H, t), 7.95 (1H, m), 8.30 (1H, m), 8.44 (2H, s) and 10.10 (1H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-2-fluorobenzonitrile, its application will become more common.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 214623-57-1, name is 5-Amino-2-methoxybenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Formula: C8H8N2O

Example 9: 2-Methoxy-5-[5-(3-morpholin-4-ylphenoxy)-pyrimidin-2-ylamino]- benzonitrileA suspension of 4-[3-(2-chloro-pyrimidin-5-yloxy)phenyl]morpholine (180mg, 0.619mmol), 5-amino-2-methoxybenzonitrile(91.7mg, 0.557mmol), in’5′(dibenzylidene-acetone)palladium(0) (28.3mg, 0.030mmol), 4,5- bi5′(diphenylphosphino)-9,9-dimethyl-xanthene (35.8mg, 0.061mmol) and cesium carbonate (403mg, 1.238mmol) in degassed 1,4-dioxane (4mL) was heated at 80C for 2 days. The suspension was diluted with ethyl acetate and washed with water and brine. The organic phase was dried (MgS04) and the solvent was removed under reduced pressure. The crude product was purified by column chromatography on silica (ethyl acetate: hexane, 1:1) to afford 2-methoxy-5-[5-(3-morpholin-4-ylphenoxy)- pyrimidin-2-ylamino]-benzonitrile as solid (113mg, 46%).Mass: (ES+) 404 (M+H)+ HPLC: 99%NMR: deltaEta ( 6-DMSO) 3.08 (4H, m), 3.69 (4H, m), 3.88 (3H, s), 6.37 (1H, dd), 6.59 (1H, br s), 6.68 (1H, dd), 7.17 (1H, d), 7.20 (1H, t), 7.86 (1H, dd), 8.12 (1H, d), 8.38 (2H, s) and 9.80 (1H, s).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 214623-57-1.

Related Products of 21524-39-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 21524-39-0 as follows.

Step A: 2-Azido-5-fluorobenzonitrile (1q): A mixture of NaN3(1.17 g, 1.8 mmol) and difluorobenzonitrile (0.5 g, 3.6 mmol) in DMA (60 mL) was heated at 100 C. for 30 minutes. The mixture was next diluted with water (300 mL) and ether (300 mL). The organic layer was washed three times with water and brine. The organic layer was dried (MgSO4) and concentrated. The crude product was purified by flash column chromatography using ether:hexane (1:5) as eluent to give the desired product (1q) as white crystals (0.3 g, 53% isolated yield). 1H NMR (400 MHz, CDCl3) delta 7.38-7.31 (m, 2H), 7.27-7.18 (m, 1H).

According to the analysis of related databases, 21524-39-0, the application of this compound in the production field has become more and more popular.