Month: May 2021

These common heterocyclic compound, 621-50-1, name is 2-(3-Nitrophenyl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: nitriles-buliding-blocks

[0308] To the mixture of solution of 3-nitrophenylacetonitrile (16.2g, 0. lmol) and ion powder (56g, lmol) in ethanol (160ml) and water (40ml), added hydrochloride (25ml, 6N), heated to reflux for 4 hours. Filtered through celite, concentrated, extracted with EtOAc, washed with water and brine, dried over sodium sulfate.Removed solvent, got crude product as oil.

The synthetic route of 2-(3-Nitrophenyl)acetonitrile has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 22433-89-2, name is 4-Bromoisophthalonitrile, A new synthetic method of this compound is introduced below., Product Details of 22433-89-2

Step b. To a stirred solution of tert-butyl 6-(acetamidomethyl)-4-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)isoindoline-2-carboxylate (1.000 g, 2.415 mmol) in 1,4-dioxane: water (9: 1, 4.4 ml) were added K2C03 (0.330 g, 2.40 mmol) and 4-bromoisophthalonitrile (CAS Number 22433-89-2; 0.250 g, 1.208 mmol) at rt. The reaction mixture was degassed for 20 min before addition of PdCl2(dppf) (0.080 g, 0.120 mmol). The resulting reaction mixture was heated at 85C for 4 h. The reaction mixture was cooled to rt, poured into water (100 ml) and extracted with EtOAc (3 x 100 ml). The combined organic phase dried over Na2S04, filtered and concentrated under reduced pressure. The residue was purified by flash column chromatography (70% EtOAc in hexane) yielding tert-butyl 6-(acetamidomethyl)-4-(2,4-dicyanophenyl)isoindoline-2-carboxylate (0.120 g, 0.288 mmol). LCMS: Method A, 1.853 min, MS: ES+ 361.58 [M-56].

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 613-46-7, name is 2-Naphthonitrile, A new synthetic method of this compound is introduced below., Safety of 2-Naphthonitrile

General procedure: Catalyst 1 (10 mol%) and HBpin (0.44 mmol) were added to aSchlenk flask inside the glove box, followed by the addition oforganic nitriles (0.2 mmol). The reaction mixture was heatedcontinuously at 65 C under neat condition or under toluene for astipulated time, as mentioned in Table 2. Toluene was then added,and the reaction mixture was filtered through a short plug of Celiteand evaporated under reduced pressure to obtain a solid residue.The diboryl amines are moisture- and air-sensitive, and henceexperimental procedures were conducted and NMR samples wereprepared inside the glove box. All products were characterizedusing multi-nuclear NMR spectroscopy, and details are given in thesupporting information.

The synthetic route of 613-46-7 has been constantly updated, and we look forward to future research findings.

Reference of 6393-40-4,Some common heterocyclic compound, 6393-40-4, name is 4-Amino-3-nitrobenzonitrile, molecular formula is C7H5N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 1. Synthesis of 3,4-Diaminobenzonitrile[0082] A solution of 4-amino-3-nitrobenzonitrile (1) (3.0 g) in ethanol (80 mL) was sparged for 5 minutes with nitrogen. Palladium on carbon (10%, 300 mg) was added and the mixture was saturated with hydrogen. The mixture was stirred under a hydrogen balloon for seven hours. The mixture was sparged with nitrogen and filtered through celite. The filtrate was concentrated in vacuo to provide the title compound, 3,4- diaminobenzonitrile (2).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Amino-3-nitrobenzonitrile, its application will become more common.

Application of 21524-39-0,Some common heterocyclic compound, 21524-39-0, name is 2,3-Difluorobenzonitrile, molecular formula is C7H3F2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: An oven-dried round bottomed flask (50 mL capacity) equipped with a magnetic stir bar was evacuated and purged with argon. 2-Aminopyridine (1 mmol, 1 euiv), 2-fluorobenzonitrile (1.2 mmol, 1.2 euiv), KtOBu (4 mmol, 4 euiv) and DMSO (5 mL) were added successivelyat room temperature and the reaction mixture was allowed to stir at room temperature for 12 h. Water (10 mL) was added to the reaction mixture and the organic layer was extracted with ethyl acetate (2×20 mL). The combined organic phases were washed with brine and dried over sodium sulfate. The solvent was removed and the residue was purified by column chromatography on silica gel using hexanes/ethyl acetate as an eluent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,3-Difluorobenzonitrile, its application will become more common.

Application of 22364-68-7, These common heterocyclic compound, 22364-68-7, name is 2-(o-Tolyl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The general procedure of the CuI catalyst based synthesis method of carbazole derivatives 3 to 8 was as follows: 50 mL two-necked round flasks dried in an oven were charged with nitrosinenamaldehyde (0.5 mmol) or nitrochalcone (0.5 mmol). ,1.0 mmol of benzyl cyanide and 5 mol% CuIdissolved with Cs2CO3(1 equiv)dissolved in 5 mL THFwere added.Each reaction mixture was then refluxed for 6-10 hours until the reaction shown by TLC at open air conditions was complete.The solvent was then removed using a rotary evaporator under reduced pressure to give a residue.The residue was purified by flash column chromatography using silica gel to separate the pure product.

The synthetic route of 22364-68-7 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 3939-09-1, These common heterocyclic compound, 3939-09-1, name is 2,4-Difluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step A – Synthesis of Intermediate Compound Int-2a To a solution of NaH (1.2 g, 30 mmol) in toluene (50 mL) was added but-3-en-l- ol (1.8 g, 25 mmol) dropwise and the mixture was allowed to stir at room temperature for 30 minutes. 2,4-Difluorobenzonitrile (4.2 g, 30 mmol) was then added in one portion and the mixture was allowed to stir at room temperature for 6 hours. Water (30 mL) was slowly added and the mixture was extracted with EtOAc and washed with brine. The organic layer was dried over anhydrous sodium sulfate and concentrated in vacuo. The crude residue was purified using flash column chromatograpy on silica gel (20: 1 PE:EtOAc) to provide compound Int-2b (4.2 g, 78%) as a yellow oil. 1H MR (400 MHz, CDC13) delta 7.51-7.53 (m, 1H), 7.20-7.25 (m, 1H), 6.79- 6.81 (m, 1H), 5.85-5.89 (m, 1H), 5.05-5.11 (m, 2H), 4.05-4.11 (m, 2H), 2.47-2.51 (m, 2H).

Statistics shows that 2,4-Difluorobenzonitrile is playing an increasingly important role. we look forward to future research findings about 3939-09-1.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 57381-51-8, name is 4-Chloro-2-fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Safety of 4-Chloro-2-fluorobenzonitrile

Cyclopentylamine and potassium carbonate were added to a DMF solution of 4-chloro-2-fluorobenzonitrile, followed by stirring at 100C for 12 hours. By post-treating the reaction liquid, 4-chloro-2-(cyclopentylamino)benzonitrile was obtained.

According to the analysis of related databases, 57381-51-8, the application of this compound in the production field has become more and more popular.

Synthetic Route of 2469-99-0,Some common heterocyclic compound, 2469-99-0, name is 3-Oxobutanenitrile, molecular formula is C4H5NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirring suspension of quinolin-5-yl-hydrazine (0.25 g, 1.6 mmol) in 3:1 ethanol/deionized water (2.5 mL) was added 3-oxo-butyronitrile (0.13 g, 1.6 mmol). The reaction mixture was then heated at 60 C. for 2 h. After cooling to room temperature, the reaction mixture was concentrated in vacuo and the resulting crude product was used directly without further purification (0.21 g, 1.5 mmol, 94%)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Oxobutanenitrile, its application will become more common.

Related Products of 766-84-7,Some common heterocyclic compound, 766-84-7, name is 3-Chlorobenzonitrile, molecular formula is C7H4ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of 0.01 mol of nitrile in 200 mL of ethanol was added a solution of 0.695 g (0.01 mol) of hydroxylamine hydrochloride in 10 mL of water, followed by the further addition of 0.420 g (0.005 mol) of sodium carbonate in 10 mL of water. The reaction mixture was stirred overnight at rt. The mixture was then concentrated to small volume under vacuum, diluted with cold water, and placed in refrigerator overnight. The precipitate that formed was recovered and recrystallized from ethanol. All amidoximes were known and characterized by comparison of their physical data with those prepared in accordance with literature procedures.1

The synthetic route of 766-84-7 has been constantly updated, and we look forward to future research findings.