Month: May 2021

Adding a certain compound to certain chemical reactions, such as: 110882-60-5, name is 3-Fluoro-5-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 110882-60-5, Recommanded Product: 3-Fluoro-5-nitrobenzonitrile

Example 1 Step 2. To solution of 1.0 eq IB in dry Et2O (0.06 M) at 00C was added dropwise a solution of diisobutyllithiumaluminum hydride (1.1 eq, 1.0 M in hexanes) by syringe. The resulting solution was kept at 00C overnight. The reaction mixture was added to a mixture of ice and glacial acetic acid. The reaction mixture was then diluted with ethyl acetate, and the aqueous layer was extracted with ethyl acetate two additional times. The combined organic layers were washed twice with saturated sodium bicarbonate, and once with brine. The organic layers were then dried over sodium sulfate, filtered and concentrated in vacuo. Purification over silica gel using 10% EtOAc/hexanes as the eluant afforded a yellow solid (100%) as an 80:20 mixture of 1C:1B. Example 1 Step 3. To cooled (00C) slurry of an 80:20 mixture of 1C:1B (1.0 eq) and boc-piperazine(about 2 eq) in a mixture of HOAc and DCM (4.8 M boc-piperazine in 1:1.4 v/v HOAc/DCM) was added sodium triacetoxyborohydride as a solid over about 5 minutes. The reaction was allowed to warm to RT and stirred for two hours. The reaction mixture was quenched with saturated sodium bicarbonate and diluted with ethyl acetate. The layers were separated and the aqueous layer was washed three times with ethyl acetate. The organic layers were combined and washed with brine, dried over sodium sulfate, and concentrated in vacuo. Purification by chromatography over silica gel using 50% ethyl acetate/hexanes as the eluant provided ID (67.7%) as a yellow oil.

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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1023971-89-2, name is 2-Bromo-6-fluoro-4-methylbenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 1023971-89-2

Example 150A 4-Bromo-6-methyl-1H-indazol-3-amine 2-Bromo-6-fluoro-4-methylbenzonitrile (4.26 g, 19.9 mmol) was dissolved in ethanol (100 mL) and treated with hydrazine hydrate (3.99 g, 79.6 mmol). After stirring at reflux for 4 h, the mixture was cooled to RT and concentrated in vacuo. The residue was dissolved in a mixture of water and ethyl acetate. The aqueous layer was extracted once more with ethyl acetate. The combined organic layers were washed with water and with brine, dried over magnesium sulfate, concentrated in vacuo and dried to yield the title compound (4.40 g, 41% of theory) in a purity of 42%. LC-MS (Method 1B): Rt=0.72 min, MS (ESIPos): m/z=226 [M+H]+

According to the analysis of related databases, 1023971-89-2, the application of this compound in the production field has become more and more popular.

Application of 2920-38-9,Some common heterocyclic compound, 2920-38-9, name is [1,1′-Biphenyl]-4-carbonitrile, molecular formula is C13H9N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In the reaction vessel was added 30mol% CuCl, the reaction tube was evacuated, filled with oxygen,In an oxygen atmosphere, 0.2 mmol of p-phenylbenzonitrile, 0.6 mmol of ammonium chloride, 1 ml of acetonitrile and 1 ml of N, N-dimethylformamide were added, the reaction vessel was sealed, and reacted at 25 C,After the reaction is completed, it is washed with water, extracted with ethyl acetate, dried and concentrated by evaporation under reduced pressure to remove the solvent. The crude product is separated by column chromatography to obtain the desired product in a yield of 70%.

The synthetic route of 2920-38-9 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1009-35-4, name is 4-Fluoro-3-nitrobenzonitrile, A new synthetic method of this compound is introduced below., Quality Control of 4-Fluoro-3-nitrobenzonitrile

Potassium hexamethyldisilazane [0.5 M in toluene] (12.04 mL, 24.08 mmol) was added to a solution of isopropanol (0.921 mL, 12.04 mmol) in tetrahydrofuran (20 mL) at 0° C. and stirred for 10 minutes. The resulting solution was added dropwise to a solution of commercially available 4-fluoro-3-nitrobenzonitrile at room temperature and stirred for several hours. Water was added and the product was extracted with ethyl acetate, dried with sodium sulfate and evaporated in vacuo to give the title compound

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 868-54-2, name is 2-Aminoprop-1-ene-1,1,3-tricarbonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 868-54-2

A 10% aqueous solution of KOH (5.60 ml, 10 mmol) andbenzyl chloride (1.15 ml, 10 mmol) were added consecutivelyto a stirred solution of of malononitrile dimer 1 (1.32 g,10 mmol) in DMF (20 ml). The mixture was stirred for 4 hat 20C and diluted with an equal volume of H2O. Theformed precipitate was filtered off, washed with H2O,EtOH, and hexane. Yield 1.80g (81%), colorless crystals,mp 140-142 (Et). IR spectrum, , cm-1: 3397-3295(N), 2219 (C?N). 1H NMR spectrum, delta, ppm (J, Hz):3.21 (1, dd, J = 7.8, J = 13.4) and 3.33 (1, dd, J = 8.6,J = 13.4, 2Ph); 4.18 (1, t, J = 8.0, CHCN); 7.27-7.36(5, m, H Ph); 8.80 (1, br. s) and 9.03 (1, br. s, NH2).Mass spectrum, m/z (Irel, %): 221 [M-]+ (100). Found, %:C 70.33; H 4.58; N 25.09. C13H10N4. Calculated, %:C 70.26; H 4.54; N 25.21.

The synthetic route of 868-54-2 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6393-40-4, name is 4-Amino-3-nitrobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., category: nitriles-buliding-blocks

A solution of 4-amino-3-nitrobenzonitrile (1) (3.0 g) in ethanol (80 mL) was sparged for 5 minutes with nitrogen. Palladium on carbon (10%, 300 mg) was added and the mixture was saturated with hydrogen. The mixture was stirred under a hydrogen balloon for seven hours. The mixture was sparged with nitrogen and filtered through celite. The filtrate was concentrated in vacuo to provide the title compound, 3,4- diaminobenzonitrile (2).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6393-40-4.

Synthetic Route of 4640-66-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4640-66-8, name is 4-Chlorophenacylcyanide, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a mixture of appropriate beta-ketonitrile (6a-c, 5.5mmol) and substituted hydrazine or hydrazine hydrochloride(6 mmol) in 20 mL of ethanol was added aqueous 2 M HCl(0.8 mL). The resulting solution was heated at 100 C for 4h. After cooling to room temperature, the mixture was concentrated under reduced pressure. The residue was poured into ice water and basified with aqueous 10% NaOH. The resulting suspension was extracted with diethyl acetate (3 x20 mL). The combined organic layers were dried over Na2SO4 and then concentrated under reduced pressure to afford the title aminopyrazoles, which were purified by crystallization from ethanol.

The chemical industry reduces the impact on the environment during synthesis 4-Chlorophenacylcyanide. I believe this compound will play a more active role in future production and life.

Related Products of 159847-81-1,Some common heterocyclic compound, 159847-81-1, name is Methyl 2-amino-5-cyanobenzoate, molecular formula is C9H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of methyl 2-amino-5-cyanobenzoate (5.68 mmol) in DCM (lOmL) was added triethyamine (8.52 mmol) followed by methyl 3-chloro-3-oxopropionate (7.38 mmol). The resulting reaction mixture was stirred at ambient temperature overnight. The reaction mixture was partitioned between EtOAc and IM HCI and the layers then separated. The organic layer washed sequentially with saturated aqueous NaHCO, followed by brine. The organic layer was diied over Na2S04, filtered, and concentrated in vacuo. The resulting residue was carried on without further purification. [00170] The residue from above was treated with 0.5M NaOMe in MeOH (6.83 mmol). The heterogenous mixture was stirred at ambient temperature for 30 min. Diethyl ether was then added to the reaction mixture and the solid was collected via vacuum filtration, washing with ether. The obtained solid was carried on without further purification. [00171] To a flask containing the solid from above cooled to 0 C was added POCK (15 mL). The mixture became warm and bubbled. The resulting reaction mixture was heated to 90C for 3 h. Cooled the dark reaction mixture to ambient temperature and poured it very slowly into stirring saturated aqueous NaHCOj cooled to 0 C. Solid NaHCQs was then added until the solution was basic. The aqueous solution was extracted with EtOAc (3x). The combined organic layers were dried over a2S04, filtered, and concentrated in vacuo. The obtained residue was purified via flash column chromatography, eluting with 9: l/hexanes:EtOAc, to yield the intermediate 13 (29% over 3 steps). MS ESI (m/z) 281 (M+ J ); ;H NMR (300 MHz, CDCi3) 5 8.63 (d, 1 H, J=l .8 Hz), 8.16 (d, 1H, ./ 8 · Hz), 8.00 (dd, lH, Hz), 4.08 (s, 3H); i C NMR (CDC , 75MHz) 5 163.4, 148.9, 148.1 , 141 .8, 1 33.3, 130.8, 130.6, 128.8, 124.3, 1 17.7, 1 12.8, 54.1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-amino-5-cyanobenzoate, its application will become more common.

Reference of 64113-84-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 64113-84-4, name is 2-Fluoro-5-methylbenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 27 N-(2-Cyano-4-methylphenyl)-4-piperidone propylene ketal (29) A solution of 2-fluoro-5-methylbenzonitrile (2.76 g, 20.4 mmol) and 4-piperidone propylene ketal (3.39 g, 21.5 mmol) in DMF (50 mL) was heated in an oil bath (90 C., 20 h). The mixture was diluted with ether and sodium carbonate solution. The aqueous layer was extracted with two additional portions of ether and the combined organic extracts were washed with brine, dried over Na2SO4, and concentrated under reduced pressure. PCTLC (SiO2, 6 mm, 50-0% hexane/CHCl3) afforded the title compound (29). 1H NMR (CDCl3, 400 MHz) consistent with assigned structure. FABLRMS m/e 273 g/mole (M++H, C16H20N2O2=273 g/mole.) HPLC (Vydac; C18; diameter=4.6 mm; length=150 mm; gradient=H2O [0.1% H3PO4]-CH3CN, 95%-5%, 5%-95%, over 16 minutes, 2 ml/min flow rate) RT=9.97 min; focus=215 nm; 97.8% pure.

The chemical industry reduces the impact on the environment during synthesis 2-Fluoro-5-methylbenzonitrile. I believe this compound will play a more active role in future production and life.

These common heterocyclic compound, 105942-08-3, name is 4-Bromo-2-fluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C7H3BrFN

a) 4-Bromo-2-methoxybenzonitrile A suspension of potassium methoxide (4.24 g, 60.0 mmol) in tetrahydrofuran (40 mL) was added in portions to a solution of 4-Bromo-2-fluorobenzonitrile (8.0 g, 40.0 mmol) in tetrahydrofuran (50 mL) at -50° C. After one hour, the dry ice bath was removed and the reaction mixture was allowed to warm up to room temperature and stirred at room temperature for 6 hours. The reaction mixture was poured onto water (250 mL) and the solid was collected by filtration to give 4-bromo-2-methoxybenzonitrile (7.85 g, 92percent). 1H NMR (DMSO-d6) delta 3.94(s, 3H), 7.32 (d, J=8.23 Hz, 1H), 7.15 (s, 1H), 7.69 (d, J=8.23 Hz, 1H).

The synthetic route of 4-Bromo-2-fluorobenzonitrile has been constantly updated, and we look forward to future research findings.