Month: May 2021

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 114772-53-1, name is 4′-Methyl-[1,1′-biphenyl]-2-carbonitrile, A new synthetic method of this compound is introduced below., Formula: C14H11N

Example 2: Production of CBAL (1) To monochlorobenzene (450 g) was added CMB (300 g, 1.55 mol), and solution prepared by dissolving sodium bromate (50.1 g, 0.33 mol) in 95.3 g of water was added. 2,2′-azobis(2-methylbutyronitrile)(2.0 g, 0.01 mol) was dissolved in monochlorobenzene(10g), and this solution was added to the above-mentioned solution at 75 to 85C, then, immediately, solution prepared by dissolving 2,2′-azobis(2-methylbutyronitrile)(89 g, 0.05 mol) in monochlorobenzene (48.8 g), and bromine (198.5 g, 1.24 mol) were dropped simultaneously respectively at 70 to 80C. The solution of 2,2′-azobis(2-methylbutyronitrile) was dropped at a rate of about 0.22 g/min and bromine was dropped at a rate of about 0.73 g/min. The added solution was stirred for 5 hours at 70 to 75C, and the reaction solution was checked under HPLC analysis conditions (1), and that the area percentage of raw materials reached 1% or less was confirmed, obtaining a mixed solution of CMBMB and CDBMB. The solution was analyzed under the HPLC analysis conditions (1), to find an area percentage of CMBMB of 63.6%, CDBMB of 36.2% and a raw material CMB of 0.2%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 127946-77-4, name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127946-77-4, Formula: C4H7ClN2

To prepare (2S,4R)-4-[2-chloro-4-((5)-2,2,2-trifluoro-1-methyl-ethoxy)-benzenesulfonyl]-1-(1-trifluoromethyl-cyclopropanecarbonyl)-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide, example 183c (200 mg) was dissolved in DMF (2.0 mL). HATU (420 mg), DIEA (143 mg) and 1-amino-1-cyclopropane carbonitrile hydrochloride were added to the solution. The obtained suspension was stirred at ambient temperature for 2 h. After that the solvent was evaporated under reduced pressure to dryness. The residue was dissolved in CH2Cl2 (25 ml), was extracted in succession with aqueous 0.5 NHCl-solution, aqueous 10% Na2CO3-solution and brine. The water layers were washed with totally CH2Cl2 (50 ml), the combined organic layers were dried over Na2SO4, filtered and evaporated. The residue was purified over silica gel chromatography with n-heptan: AcOEt to yield 130 mg (59%) of the title compound as colorless amorphous solid. MS (ESI): m/z=602.1 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Amino-1-cyclopropanecarbonitrile hydrochloride, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 17626-40-3, These common heterocyclic compound, 17626-40-3, name is 3,4-Diaminobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a stirred solution of alkyne (0.2 mmol) in DMSO (2.0 mL) was added I2 (10.1 mg, 0.04 mmol). The solution was stirred at 130 oC for 24 h in air. Then the mixture was cooled to room temperature, and o-Phenylenediamine (0.3 mmol) was added. The solution was stirred at room temperature for 1 h. After completion, the solution was diluted with ethyl acetate, washed with H2O, dried over MgSO4, and concentrated in vacuo. The residue was purified by preparative thin-layer chromatography on silica gel with PE/EtOAc (15/1) as an eluent to give quinoxaline 3.

Statistics shows that 3,4-Diaminobenzonitrile is playing an increasingly important role. we look forward to future research findings about 17626-40-3.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 654-01-3, name is 2-(2,6-Difluorophenyl)acetonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-(2,6-Difluorophenyl)acetonitrile

Example 13; Preparation of 1-(2,6-difluorophenyl)cyclopropanecarboxylic acid amide. 1-(2,6-Difluorophenyl)cyclopropanecarbonitrile was prepared as described in U.S. Pat. No. 4,859,232 by alkylation of 2,6-difluorophenylacetonitrile with 1,2-dibromoethane in 50% sodium hydroxide in the presence of catalytic amounts of tetrabutylammonium bromide (quantitative yield; GC/MS: m/z 179, RT 8.24 min.; 1H-NMR (DMSO-d6): delta 7.58-7.48 (m, 1H), 7.24-7.16 (m, 2H), 1.84-1.79 (m, 2H), 1.46-1.41 (m, 2H)).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 34667-88-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 34667-88-4, name is 2-Fluoro-4-nitrobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

[00293] A solution of 2-fluoro-4-nitrobenzonitrile (0.541 g, 2.43 mmol) in methanol (20 mL) and 6N hydrochloric acid (3 mL) was hydrogenated (55 psi) over 10percent palladium on carbon (164 mg) for 22 li. The reaction mixture was filtered and concentrated in vacuo to afford 77A (0.65 g, 100percent). 1H NMR (400 MHz, CD3OD) delta 4.23 (s, 2 H), 7.29 (d, J=8.79 Hz, 2 H), 7.68 (t, J=I.91 Hz, 1 H).

The synthetic route of 2-Fluoro-4-nitrobenzonitrile has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 16932-49-3, name is 2,6-Dimethoxybenzonitrile, molecular formula is C9H9NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C9H9NO2

EXAMPLE 69: Preparation of N-[2-Hydroxy-3-(2-cyano-3-methoxyphenoxy)propyl]-1,1-dimethyl-2-(4-methoxyphenyl) ethylamine Hydrochloride, Compound 118 STR69 Powdered sodium cyanide (9.0 g, 184 mmol) and 2,6-dimethoxybenzonitrile were added to 50 mL of dimethylsulfoxide and heated to 145 C. for 110 min under nitrogen. The reaction was cooled and poured into ether and dilute HCl. The ether layer was separated, washed twice with dilute acid, once with saturated brine, dried over anhydrous sodium sulfate, and concentrated. The yield of 2-cyano-3-methoxyphenol was 8.1 g.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 16932-49-3, its application will become more common.

Application of 214623-57-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 214623-57-1, name is 5-Amino-2-methoxybenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

Sodium nitrite (l.llg, 16.17 mmol) in water (5 ml) was added with stirring over 15 min to a cold (0 C) solution of A (2.18 g,14.7 mmol) in concentrated hydrochloric acid (7 ml) and ice (10 g). The mixture was stirred at 0 C for a further 20 min. and the cold solution was added over 30 min to a stirred solution (room temperature) of potassium iodide (12.2 g, 73 mmol) in water (15 ml). The mixture was left standing at room temperature overnight and extracted with dichlormethane (2×50 ml). The combined organic extracts were washed successively with 10% NaOH, water, and dried (Na2S04). Evaporation of the solvent and silica gel column chromatography of the residue (Hexanes/EtOAc) gave iodide B (3.46 g, 80%).

The chemical industry reduces the impact on the environment during synthesis 5-Amino-2-methoxybenzonitrile. I believe this compound will play a more active role in future production and life.

Synthetic Route of 135748-35-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 135748-35-5, name is 4-Chloro-2,5-difluorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

a [3-(5-Chloro-2-cyano-4-fluorophenoxy)hexyl]methylcarbamic Acid, 1,1-dimethylethyl Ester The subtitle compound was prepared according to the method of Example 3 step (b) using (3-hydroxyhexyl)methylcarbamic acid, 1,1-dimethylethyl ester and 4-chloro-2,5-difluorobenzonitrile in N,N-dimethylformamide. 1H NMR 300 MHz (CDCl3) 7.33 (1H, d), 6.99 (1H, bs), 4.33 (1H, m), 3.34 (2H, m), 2.85 (3H, s), 1.95 (2H, m), 1.70 (2H, m), 1.41 (11H, m), 0.95 (3H, t).

The synthetic route of 4-Chloro-2,5-difluorobenzonitrile has been constantly updated, and we look forward to future research findings.

Electric Literature of 6609-57-0,Some common heterocyclic compound, 6609-57-0, name is 2-Ethoxybenzonitrile, molecular formula is C9H9NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Trifluoroacetic acid (4 mL) was added to a mixture of nitrile(1.0 mmol) and thiosemicarbazide (1.1 mmol). The reaction mixturewas stirred and refluxed for 6 h. Then, it was cooled to roomtemperature and aqueous ammonia was added. The precipitatedsolidwas filtered,washed with hot water and air-dried. It should benoted that the compounds f1-f35 were directly used for the nextreaction without further purification.

The synthetic route of 6609-57-0 has been constantly updated, and we look forward to future research findings.

Electric Literature of 118431-88-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 118431-88-2, name is 3-Cyclopropyl-3-oxopropanenitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Hydrazine hydrochloride 14a or b was refluxed with nitrile 12a,b or c in EtOH overnight. The reaction solution was evaporated in vacuo to furnish the corresponding pyrazolo amine, which was used without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Cyclopropyl-3-oxopropanenitrile, other downstream synthetic routes, hurry up and to see.