Month: May 2021

Related Products of 1835-65-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1835-65-0 as follows.

Nickel complexes 3?6. A mixture of 1.00 g (3.2 mmol) of nitrile 1, 0.64 g (3.2 mmol) of nitrile 2, and 0.50 g (2.0 mmol) of nickel(II) acetate tetrahydrate was stirred during 1 h at 210 °C. After cooling the reaction mixture, it was dissolved in 50 mL of dichloromethane and filtered through a 5 cm layer of type II alumina. The solvent was distilled off, and the residue was purified by column chromatography on Kieselgel 60 silica gel (Merck). First, complexes 3 and 4 were isolated using dichloromethane as eluent, and then complexes 5 and 6 were isolated using a 95 : 5 (v/v) mixture of dichloromethane and ethanol as eluent.

According to the analysis of related databases, 1835-65-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Koptyaev; Galanin; Shaposhnikov; Russian Journal of General Chemistry; vol. 86; 4; (2016); p. 854 – 858; Zh. Obshch. Khim.; vol. 86; 4; (2016); p. 667 – 671,5;,
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Related Products of 13388-75-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13388-75-5, name is 2-(3,5-Dimethoxyphenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A 50 mL round-bottomed flask was charged with 3 (0.177 g, 1 mmol), aromatic aldehyde or substituted aromatic aldehyde (1 mmol) and 10 mL methanol with stirring, and the mixture was heated to 60 C. After 30 min, sodium methoxide (0.027 g, 0.5 mmol) was added to the mixture and keep the temperature for 4-6 h. After completion of the reaction as indicated by TLC, the reaction mixture was cooled to RT, and the precipitate was separated by filter and recrystallized from methanol to give 4a-4z and 5a-5d.

The chemical industry reduces the impact on the environment during synthesis 2-(3,5-Dimethoxyphenyl)acetonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Article; Ma, Jun; Li, Jiajun; Tian, Yu-Shun; Bioorganic and Medicinal Chemistry Letters; vol. 27; 1; (2017); p. 81 – 85;,
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These common heterocyclic compound, 50594-78-0, name is 5-Fluoro-2-nitrobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 5-Fluoro-2-nitrobenzonitrile

The 4-chloro-6-(1,2,4-triazol-1-yl)quinazoline used as a starting material was obtained as follows: A mixture of 5-fluoro-2-nitrobenzonitrile (3 g), 1,2,4-triazole (4.92 g), triethylamine (9.9 ml) and DMSO (50 ml) was stirred and heated to 85 C. for 16 hours. The mixture was cooled to ambient temperature and water was added. The precipitate was isolated and dried to give 2-nitro-5-(1,2,4-triazol-1-yl)benzonitrile (1.9 g) which was used without further purification.

The synthetic route of 5-Fluoro-2-nitrobenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zeneca Limited; US5955464; (1999); A;,
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These common heterocyclic compound, 501-00-8, name is 2-(3-Fluorophenyl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C8H6FN

To a solution of compound 36-2 (346 mg, 2.56 mmol) in THF (10 niL) was added Raney Ni. Then the mixture was adjusted to PH=IO with concentrated aqueous ammonia and stirred at 30 0C overnight. TLC showed the reaction was completed. The mixture was filtered through Celite and the filtrate was concentrated to give 36-3 as a yellow oil (120 mg, yield: 34 %).

The synthetic route of 2-(3-Fluorophenyl)acetonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY; YUAN, Junying; MA, Dawei; LIU, Junli; ZHANG, Lihong; WO2011/11522; (2011); A2;,
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Synthetic Route of 873-32-5, A common heterocyclic compound, 873-32-5, name is 2-Chlorobenzonitrile, molecular formula is C7H4ClN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: An oven-dried reaction tube was charged with Ni(MOTPP)2(1-naphthyl)Cl (2mol%, relative to aryl chloride), K3PO4 (3 equiv., relative to aryl chloride), and phenylboronic acid (1.5 equiv., relative to aryl chloride). Solid aryl chlorides (0.5mmol) were also added at this time. The tube was evacuated and purged with nitrogen for three times. 1,4-dioxane (2mL) and degassed water (0.2mL) were added via syringe. Liquid aryl chlorides were also added via syringe with the solvents. The mixture was stirred at 100C for 1h under a nitrogen atmosphere, and then cooled to room temperature. The reaction mixture was extracted with ethyl acetate, and the organic layers were dried over anhydrous Na2SO4. The organic phase was evaporated under reduced pressure, and the residue was purified by column chromatography on silica gel with hexane/ethylacetate as the eluent to afford the desired product. The products were identified by gas chromatography and NMR spectra.

The synthetic route of 873-32-5 has been constantly updated, and we look forward to future research findings.

Reference:
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Application of 40497-11-8,Some common heterocyclic compound, 40497-11-8, name is Ethyl 2,3-dicyanopropanoate, molecular formula is C7H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

0.01 mol of ethyl 2,3-dicyanopropionate was added to a three-necked flask. The prepared diazonium salt solution was dropped into the flask. The reaction was complete for 2 h. Adding aqueous ammonia, adjust the pH to 9-10. Reaction at room temperature for 2h. After completion of the reaction, the reaction mixture was extracted with 40 mL of dichloromethane. The organic layer was washed with water (2 x 30 mL), washed with saturated sodium chloride solution (1 x 40 mL), and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give 1.56 g of product, yield 48.8%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 2,3-dicyanopropanoate, its application will become more common.

Reference:
Patent; Nanjing University of Technology; Wan, Rong; Wu, Shaohua; Guo, Chunwei; Guan, Xilin; Chen, Fuli; Han, Zhenyu; Fu, Xiaohuan; (14 pag.)CN105601632; (2016); A;,
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Reference of 14447-18-8, These common heterocyclic compound, 14447-18-8, name is Benzyl cyanoacetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To 0.2 mmol of 3,4-dihydroxycinnamaldehyde in 3 mL EtOH a corresponding substituted acetonitrile or the like was added followed by addition of 0.4 mmol of piperidine. A dark red solution was stirred at 20 °ree;C for 0.5 h. 0.5 mL 1 N HC1 and 5 mL of H2O were added and EtOH was evaporated with the stream of N2. The precipitated powder was filtered off, washed with H2O and dried in a desiccator in vacuo in the presence of solid NaOH. Yields were 55-70%. For a list of obtained products (CRIX-38, CRIX-39, CRIV-42, CRIV-46, CRTX-79, CRVIII-33, CRVIII-34, CRVIII-50, CRVIII-51, CRVIII-52, CRVIII-53) see Tables 1 and 5. For the mass spectra and UV maxima see Tables 2 and 6. For the NMR data see Tables 3 and 7.

Statistics shows that Benzyl cyanoacetate is playing an increasingly important role. we look forward to future research findings about 14447-18-8.

Reference:
Patent; THE HOSPITAL FOR SICK CHILDREN; WO2005/12234; (2005); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1835-65-0, name is 3,4,5,6-Tetrafluorophthalonitrile, A new synthetic method of this compound is introduced below., Formula: C8F4N2

Tetrafluorophthalonitrile (37 g, 183 mmol) was added to 1-chioronaphthalene (150 ml) in which BC13 (14 g, 120 mmol) was dissolved, and the mixture was heated to reflux under a nitrogen atmosphere. After cooling, the mixture was separated and purified by silica chromatography, and then a product was purified by sublimation and purification to obtain F12-SubPc-Cl (5.3 g, yield 64percent).

The synthetic route of 1835-65-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SONY SEMICONDUCTOR SOLUTIONS CORPORATION; OBANA, Yoshiaki; NEGISHI, Yuki; HASEGAWA, Yuta; TAKEMURA, Ichiro; ENOKI, Osamu; MOGI, Hideaki; MATSUZAWA, Nobuyuki; (67 pag.)US2017/54089; (2017); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89001-53-6, name is 2-Methyl-4-nitrobenzonitrile, A new synthetic method of this compound is introduced below., SDS of cas: 89001-53-6

3-Methyl-4-oxazol-5-yl-phenylamine was prepared in two steps from 2-methyl-4- nitrobenzaldehyde in analogy to intermediate 1. 2-Methyl-4-nitrobenzaldehyde was preparedaccording to the following procedure:2-methyl-4-nitrobenzonitrile (1 g, 6.1?7 mmol) was dissolyed in dry toluene (24.0 ml). After cooling to 0C, a solution of DIBAL-H (4.35 ml, ?7.4 mmol) in toluene was added drop wise oyer 10 min. The mixture was stirred for 2h at 0C. The mixture was quenched at 0C by addition of HC1 2N (1 ml). After warming to room temperature and addition of further HC1 2N (1 ml),sodium sulfate was added under yigorous stirring. Filtration of the solids and eyaporation yielded a crude, which was purified by flash chromatography (heptane/AcOEt), to yield 2- methyl-4-nitrobenzaldehyde as an orange solid (0.68 g, 67%)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CECCARELLI, Simona M.; JAGASIA, Ravi; JAKOB-ROETNE, Roland; PETERS, Jens-Uwe; WICHMANN, Juergen; WO2014/79850; (2014); A1;,
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Synthetic Route of 53078-71-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53078-71-0, name is 4-Methoxy-3-methylbenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

c) 4-Hydroxy-3-methylphenylcyanide. To a solution of 4-methoxy-3-methylphenylcyanide (11b, 44.8 g, 0.3044 mol) in 150 ml of methylene chloride, chilled to 0 C. with stirring under nitrogen, was added 575 ml (0.575 mol) of boron tribromide (1M in methylene chloride) in a steady stream, and the mixture was stirred at room temperature for 24 h. The reaction mixture was refluxed overnight, additional boron tribromide (44.7 ml) was added at 25 C. and the mixture was stirred at room temperature for 30 min, refluxed for 3 h, and then stirred at room temperature for 48 h. The indicated the presence of the starting nitrile, and therefore, the third addition of boron tribromide (60.88 ml) was made and the mixture was refluxed overnight. The reaction mixture was chilled to 0 C. in an ice bath, 175 ml of methanol was added dropwise, and 600 ml of water was added. The resulting mixture was stirred overnight. The aqueous layer was extracted with methylene chloride (2x), the organic layer was washed with 10% NaOH solution (3x). The basic aqueous layer was acidified to pH=5 with 6N HCl solution (product oiled out), the mixture was extracted with methylene chloride(3x), and the organic layer was washed with brine and dried over magnesium sulfate. The methylene chloride solution was filtered through Florisil and concentrated in vacuo to provide 38.2 g of the title compound as a pale yellow solid, m.p. 95.5-97 C.

The synthetic route of 4-Methoxy-3-methylbenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sterling Winthrop Inc.; US5464848; (1995); A;,
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