Adding a certain compound to certain chemical reactions, such as: 94087-40-8, name is 3-Chloro-2-fluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 94087-40-8, name: 3-Chloro-2-fluorobenzonitrile
To a solution of 11 (3.57 g, 16.9 mmol, 1 eq) and 3-chloro-2-fluorobenzonitrile (5.25 g, 33.74 mol, 2 eq) in dry DMSO (125 mL) was added K2CO3 (7 g, 50.6 mmol, 3.1 eq). The reaction mixture was stirred at rt for 24 h and partitioned between EtOAc and brine. The aqueous phase was extracted with EtOAc and the combined EtOAc extracts were washed with brine, dried over Na2SO4, and evaporated. Chromatography on a silica column with eluent of 20:1 CH2Cl2:Me0H afforded (R)-3-chloro-2-[2-chloro-5-(5-oxo-pyrrolidin-3-yl> phenoxy]-benzonitrile, 12. 2.4 Results[0172] Analytical data for structure 9 is provided below.2.4a (R)-3-chloro-2-[2-chloro-5-(5-oxo-pyrrolidin-3-yl)’phenoxy]-benzonit}”ile [0173] MS m/z 347.0 (M + 1).
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Reference:
Patent; IRM LLC; WO2006/81554; (2006); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts