Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51762-67-5, name is 3-Nitrophthalonitrile, A new synthetic method of this compound is introduced below., Safety of 3-Nitrophthalonitrile
The K2CO3 (18.24 g) and NaNCh (8.27 g) were added to a stirring solution of 3-nitrophthalonitrile (1, 20.8 g, 120 mmol) in DMSO (90 mL) at ambient temperature. The resulting suspension was gently refluxed (oil bath) for 1.5 h. After the resulting hot black reaction mixture was poured into cold water (750 mL), pH was adjusted to 3 with concentrated HC1 (~25 mL) to give an orange suspension, which was kept in freezer for 30 min. The precipitate was collected by vacuum filtration, raised with H20/EtOH and kept under vacuum for overnight to give crude 3-hydroxylphthalonitrile. The product was used for next step without further purification.
The synthetic route of 51762-67-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CITY OF HOPE; KORTYLEWSKI, Marcin; SWIDERSKI, Piotr, Marek; ROSEN, Steven; (218 pag.)WO2019/241766; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts