Some common heterocyclic compound, 6609-57-0, name is 2-Ethoxybenzonitrile, molecular formula is C9H9NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 2-Ethoxybenzonitrile
Add 97% in a 250mL four-necked bottleCompound IV 15.2g (0.1mol),9g (0.13mol) of hydroxylamine hydrochloride,17.9g (0.13mol) was added to 100mL of ethanol,The reaction was refluxed for 4 h.TLC traces the reaction to Compound IV completely, drops to room temperature, and removes the potassium salt in the reaction solution by filtration.The filtrate was evaporated to 80% ethanol, and a white solid precipitated upon cooling.Filter by suction and recover the filtrate.A white solid was obtained in an amount of 16.2 g, yield 90%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6609-57-0, its application will become more common.
Reference:
Patent; Qingdao University of Science and Technology; Xu Liangzhong; Cui Jianqiang; Zhang Mingming; Liu Liancai; Hu Rao; Wang Minghui; (6 pag.)CN108341808; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts