Application of 145689-34-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 145689-34-5, name is 2-(2,3-Difluorophenyl)acetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a mixture of (2,3-difluorophenyl)acetonitrile (40.5 g, 265 mmol), ethyl acrylate (24 mL, 221 mmol), and hydroquinone (50 mg, 0.45 mmol) was added KOH (2 M in MeOH, 2.0 mL, 4.0 mmol) and the resulting mixture was heated at 160 C for 16 h and then allowed to cool to ambient temperature. The crude mixture was purified by silica gel chromatography, eluting with a gradient of hexanes:EtOAc – 100:0 to 50:50, to give the title compound. MS: mlz = 207.9 (M – OEt).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2,3-Difluorophenyl)acetonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; BELL, Ian, M.; FRALEY, Mark, E.; GALLICHO, Steven, N.; MITCHELL, Helen, J.; WANG, Chang; WO2012/129014; (2012); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts