Electric Literature of 103146-25-4,Some common heterocyclic compound, 103146-25-4, name is 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile, molecular formula is C20H23FN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A test tube equipped with a stopper was charged with 10 mg (0.029 m mol) of [()-4-] [ [4-DIMETHYLAMINO-L- (4′-FLUOROPHENYL)-L-HYDROXYBUTYL]-3-HYDROXYMETHYLBENZONITRILE,] 10 mg [OF NOVOZYM 435] (product [OF NOVOZYMES),] 0.29 m mol of various kinds of acyl donor and 1 ml of diisopropyl ether, and stirred at [30C] for 16 hours. For the substrate with the optical purity of at least 30% ee, E-values were calculated. The results are shown in Table 8.
The synthetic route of 103146-25-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; H. LUNDBECK A/S; WO2004/14821; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts