Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6609-57-0, name is 2-Ethoxybenzonitrile, A new synthetic method of this compound is introduced below., Safety of 2-Ethoxybenzonitrile
To a 250 mL three-necked flask, 100 mL of ethanol, 13.8 g (0.2 mol) of hydroxylamine hydrochloride and 20 g (0.2 mol) of triethylamine were added, and the mixture was heated to 50-60 C for 1 h, and free hydroxylamine hydrochloride. After 1 h, 18 g of compound 4 (o-ethoxybenzonitrile) was added to the flask, and the mixture was refluxed for 2 h. The compound 4 disappeared by TLC. Ethanol was distilled off, and 150 mL of water was added to the flask to dissolve the triethylamine hydrochloride. The mixture was filtered under suction, and the cake was compound 3, which was dried to give a white solid.
The synthetic route of 6609-57-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Qingdao University of Science and Technology; Xu Liangzhong; Sun Jianxin; Zhang Mingming; Cui Huanqi; Hu Rao; Wang Minghui; (6 pag.)CN108912106; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts