Electric Literature of 34662-29-8, These common heterocyclic compound, 34662-29-8, name is 3-Chloro-4-nitrobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 3-chloro-4-nitrobenzonitrile (620 mg, 2.4 mmol, Chem. Pharm. Bull, (1992) 2399-2404), 1,1-carbonyldiimidazole (778 mg, 4.8 mmol) in tetrahydrofurane (30 ml) was stirred at room temperature overnight. To the mixture was added water (30 ml) and the whole was extracted with ethyl acetate (100 ml×2). The combined organic layers were washed with brine, dried over sodium sulfate, and concentrated in vacuo. The residue was purified by column chromatography on silica gel (hexane/ethyl acetate=1/1 as eluent) to afford the titled compound as a white solid (415 mg, 65%). [0455] 1H-NMR (CDCl3) delta:10.96 (s, 1H), 7.17-7.30 (m, 2H), 7.05 (d, J=8.1 Hz, 1H), 6.89 (d, J=1.3 Hz, 1), 4.07 (t, J=7.0 Hz), 3.02 (t, J=7.0 Hz, 2H) ppm.
Statistics shows that 3-Chloro-4-nitrobenzonitrile is playing an increasingly important role. we look forward to future research findings about 34662-29-8.
Reference:
Patent; Ando, Kazuo; Kawai, Makoto; Kawamura, Mitsuhiro; Matsumizu, Miyako; Morita, Asato; Sakurada, Isao; US2004/204409; (2004); A1;,
Nitrile – Wikipedia,
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