Application of 57381-51-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 57381-51-8 name is 4-Chloro-2-fluorobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a 3 L round bottom flask were added 4-chloro-2-fluorobenzonitrile (100 g, 0.64 mol) and methyl thioglycolate (70.0 ml, 0.77 mol) add 1.2 L of N, N-dimethylformamide and lower the internal temperature to -5 C. Sodium tert-butoxide (93.67 g, 0.96 mol) is slowly added, ensuring that the internal temperature does not exceed 0 C. After stirring at room temperature for 2 hours, Drop the reaction slowly into cold water. The resulting solid was stirred at room temperature, filtered, Drying afforded intermediate A-1. (142.9 g, 92%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Chloro-2-fluorobenzonitrile, and friends who are interested can also refer to it.
Reference:
Patent; Samsung SDI Co., Ltd; Samsung Electronics Co., Ltd.; Kim Byeong-gu; Kang Gi-uk; Kim Hyeong-seon; Ryu Dong-wan; Shin Chang-ju; Lee Han-il; Jang Gi-po; Jeong Seong-hyeon; (69 pag.)KR2019/32884; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts