5653-62-3, name is 2,3-Dimethoxybenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 2,3-Dimethoxybenzonitrile
2,3-Dimethoxybenzonitrile (2.0 g, 12.3 mmol), ZnBr2 (2.8 g, 12.3 mmol), and sodium azide (0.88 g, 13.5 mmol) were suspended in H2O (25 mL) and iPrOH (3 mL) and heated behind a blast shield at reflux for 24 hours. The mixture was allowed to cool to ambient temperature and diluted with EtOAc and 2N HCl. The aqueous phase was back extracted with EtOAc and the combined organic phases were dried over Na2SO4, filtered through a 1/4″ silica gel plug, and the filtrate was concentrated under reduced pressure. The residue was purified by trituration with diethyl ether to provide the title compound. MS (DClTNH3) m/z 207 (MH-H)+, m/z 181 (M+NH4-HN3)+.
The synthetic route of 5653-62-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ABBOTT LABORATORIES; WO2006/86229; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts