A new synthetic route of 499983-13-0

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 499983-13-0, its application will become more common.

Some common heterocyclic compound, 499983-13-0, name is 4-Bromo-3-fluorophenylacetonitrile, molecular formula is C8H5BrFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: nitriles-buliding-blocks

A suspension of (4-bromo-3-fluorophenyl)acetonitrile (20 g; see step (ii) above) in cone. HCl (100 mL) was stirred at 8O0C overnight. The reaction mixture was basified with saturated NaHCO3 (aq.) and then extracted with ethyl acetate. The aqueous layer was acidified with cone. HCl and filtered to provide 8.2 g of the sub-title compound as a pink solid. This was employed directly in the next step without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 499983-13-0, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; WO2007/69986; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts