Related Products of 4640-66-8,Some common heterocyclic compound, 4640-66-8, name is 4-Chlorophenacylcyanide, molecular formula is C9H6ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: General procedure: The substrate 1 (1.0 mmol) and thiourea 2(2.0 mmol) were added to solvent (5 mL methanol) at room tem-perature. To the reaction mixture, TBHP (3.0 mmol) and AIBN(0.2 mmol) were added respectively. The reaction mixture wasstirred at room temperature (for substrates 1a-f) or reux tem-perature (for substrates 1g-r) until TLC indicated the total consumption of 1 (for substrates 1p-q, the reaction time is 24 h).The residue was treated with saturated aqueous NaHCO3 (50 mL)and then extracted with EA (30 mL 3). The organic phase waswashed with brine (50 mL 1), dried over anhydrous Na2SO4. Thesolvent was removed and the residue was puried by ash columnchromatography on silica gel (EA/PE) to afford the desired compound 3.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Chlorophenacylcyanide, its application will become more common.
Reference:
Article; Sun, Jiyun; Ge, Huaibin; Zhen, Xiaohua; An, Xuechan; Zhang, Guangtao; Zhang-Negrerie, Daisy; Du, Yunfei; Zhao, Kang; Tetrahedron; vol. 74; 17; (2018); p. 2107 – 2114;,
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