Adding a certain compound to certain chemical reactions, such as: 117482-84-5, name is 3-Chloro-4-fluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 117482-84-5, Recommanded Product: 117482-84-5
A 1 L flask was charged with the product E obtained above (27.2 g 122.3 mmol, 1.0 equiv), 23.13 g 3-chloro-4-fluorobenzonitrile (122.3 mmol, 1.0 equiv), 49.8 g cesium carbonate (152.9 mmol, 1.25 equiv) and 200 mL DMF. The flask was equipped with a reflux condenser, and then placed into a preheated 110 C bath with stirring for 1 h under a dry N2 atmosphere. The resulting suspension was then cooled, diluted with H20 and extracted with 50% EtOAc/ Et20. The organics were washed with brine, dried with Na2S04 and concentrated under reduced pressure. Purification of the residue by flash chromatography (Si02, 20% EtOAc/Hexane) provided 33 g of the product as a white solid (90.4 mmol). ‘H NMR (500 MHz, CDC13): 8 1.86 (s, 3H), 2.82 (s, 1H), 6.80 (J= 8.5 Hz, 1H), 7.33 (dd, J = 8.5,1.5 Hz, 1 H), 7.59 (d, J= 8.5 Hz, 2H), 7.64 (s, 1H), 7.73 (d, J= 8.5 Hz, 2H).
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Reference:
Patent; AMGEN, INC.; WO2005/110980; (2005); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts