In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 628-20-6 as follows. Quality Control of 4-Chlorobutyronitrile
EXAMPLE 56 5-(3-CHLOROPROPYL)TETRAZOLE A mixture of 3.5 g of 4-chlorobutyronitrile, 2.3 g of sodium azide and 1.9 g of ammonium chloride in 50 ml of dimethyl-formamide is stirred at 140 C. for 20 hours. The reaction mixture is poured onto ice, basified with 1N sodium hydroxide and extracted twice with ethyl acetate. The aqueous fraction is acidified with acetic acid and extracted with ethylacetate. Evaporation of the ethyl acetate gives 5-(3-chloropropyl)-tetrazole which is used directly in the next step.
According to the analysis of related databases, 628-20-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Aventis Pharma Deutschland GmbH; US6376512; (2002); B1;; ; Patent; Jaye, Michael; Duverger, Nicolas; Searfoss, George; Minnich, Anne; US2003/220373; (2003); A1;,
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