Adding a certain compound to certain chemical reactions, such as: 36282-26-5, name is 2-Bromo-4-fluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 36282-26-5, Product Details of 36282-26-5
Example 16 2-bromo-4-(2,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)benzonitrile (Intermediate 16) Pyrrole (2,6,6-trimethyltetrahydroindol-4-one) (1.5 g, 8.5 mmol) and 2-bromo-4-fluorobenzonitrile (1.69 g, 8.5 mmol) are dissolved in anhydrous DMF (50 mL). To this NaH (95%, 408 mg, 17.0 mmol) is added and stirred at 50 C. for 1 h. The reaction mixture is cooled to RT and H2O is added. Product crashed out of solution and is filtered and dried under vacuo (2.4 g, 79%).
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Reference:
Patent; Hall, Steven E.; (44 pag.)US2015/329493; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts