Application of 621-03-4, These common heterocyclic compound, 621-03-4, name is 2-Cyano-N-phenylacetamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture OF CYANOACETANILIDE (0.80 g, 5 mmol), 4-methoxy-3-buten-2-one (1 g, 10 mmol) and 1, 4-diazabicyclo [2,2, 2] octane (0.55 g, 5 mmol) in diethyleneglycol monomethylether was heated to 125 C for 5 h. The reaction mixture was partitioned between dichloromethane (100 ml) and 2M hydrochloric acid (100 ml). The organic layer was separated, washed with water, dried, filtered and evaporated. The residue was chromatographed on silica using heptane/ethyl acetate (1: 1) as eluent, affording the title compound (660 mg, 63%). ‘H NMR (CDCl3) : delta 7.78 (1H, d); 7.52 (3H, m); 7.17 (2H, dd); 6.22 (1H, d); 2.06 (3H, s)
Statistics shows that 2-Cyano-N-phenylacetamide is playing an increasingly important role. we look forward to future research findings about 621-03-4.
Reference:
Patent; ASTRAZENECA AB; WO2004/43924; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts