Electric Literature of 6136-93-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6136-93-2, name is 2,2-Diethoxyacetonitrile, This compound has unique chemical properties. The synthetic route is as follows.
2,2-Diethoxyacetonitrile 1 (25 g, 193 mmol) was mixed with (NH4)25 (40 mL, 265 mmol, 45% aq. solution in) in 300 mL of methanol (MeOH) at room temperature (RT). After keeping the reaction mixture overnight, it was concentrated under vacuum and the residue was taken up in ethyl acetate (EtOAc). The EtOAc solution was washed with saturatedNaHCO solution then brine and dried over anhydrous Na2504. The EtOAc was evaporated to give thioamide 2 (26 g, 159 mmol, 82%) as a white solid. ?H NMR (400 MHz, CDC13) oe 5.01 (s, 1H), 3.67 (m, 4H), 1.22 (t, J=7.2 Hz, 6H).
The chemical industry reduces the impact on the environment during synthesis 2,2-Diethoxyacetonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Patent; E. R. SQUIBB & SONS, L.L.C.; Cheng, Heng; Gangwar, Sanjeev; Cong, Qiang; (82 pag.)US9226974; (2016); B2;,
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