Adding a certain compound to certain chemical reactions, such as: 17823-40-4, name is 4-Bromo-2,3,5,6-tetrafluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17823-40-4, Application In Synthesis of 4-Bromo-2,3,5,6-tetrafluorobenzonitrile
6-Bromo-3-amino-4,5,7-1H-indazole; A solution of 5 g of 4-bromo-2,3,5,6-tetrafluorobenzonitrile in 90 mL of ethanol is admixed with 9.7 mL of hydrazine hydrate. The reaction mixture is stirred for 17 hours at reflux and then concentrated under reduced pressure. The residue obtained is stirred for 30 minutes in 80 mL of distilled water. The suspended solid is isolated by filtration, washed with water, treated with suction and then triturated in 200 mL of ethyl ether and isolated by filtration, to give 1.03 g of 6-bromo-3-amino-4,5,7-1H-indazole, whose characteristics are as follows: MS spectrum (ES+): m/z=267 [MH+]
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Reference:
Patent; Aventis Pharma S.A.; US2007/161626; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts