Adding a certain compound to certain chemical reactions, such as: 51762-67-5, name is 3-Nitrophthalonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 51762-67-5, Safety of 3-Nitrophthalonitrile
3-Hydroxypthalonitrile was synthesized according to the literature method [22]. To a 50 mL round-bottom flask were added 3-nitropthalonitrile (2.0 g, 11.6 mmol), K2CO3 (1.8 g, 12.7 mmol) and NaNO2 (0.8g, 11.6 mmol) in DMSO (30 mL), and the reaction mixture was stirred under reflux for 30 min. After cooling to room temperature, the reaction mixture was diluted with water (90 mL) and subsequently acidified with 2M HCl to pH=3 to produce a precipitate. Then, the solid was collected by filtration and washed successively with water and methanol. The pure product was obtained by recrystallization in acetic acid as a brown crystal (0.8 g, 48%). Mp: 263-265C.
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Reference:
Article; Chen, Wenqiang; Chen, Song; Zhou, Bingjiang; Wang, Hongbo; Song, Xiangzhi; Zhang, Hongyan; Dyes and Pigments; vol. 113; (2015); p. 596 – 601;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts