Reference of 51762-67-5,Some common heterocyclic compound, 51762-67-5, name is 3-Nitrophthalonitrile, molecular formula is C8H3N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of 3-nitrophthalonitrile (1.72 g, 0.01 mol), methyl hydroxybenzoate (0.01 mol), and potassium carbonate (13.90 g, 0.1 mol) in DMF (80 mL) was heated at 80 C overnight. Then the reaction mixture was poured into ice water. After filtration, the solid product was purified by silica-gel chromatography using CH2Cl2 as eluent to give a white solid product.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Nitrophthalonitrile, its application will become more common.
Reference:
Article; Bai, Ming; Zhang, Yan; Song, Rui; Han, Senjian; Wan, Peihong; Zhang, Chongxi; Dyes and Pigments; vol. 97; 3; (2013); p. 469 – 474;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts