Electric Literature of 51762-67-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 51762-67-5 name is 3-Nitrophthalonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
The compounds 4-hydroxy-3-methoxybenzoic acid (0.97g, 5.78mmol) and 3-nitrophthalonitrile (1.0g, 5.78mmol) were dissolved in dry DMF (30ml) and anhydrous K2CO3 (1.59g, 11.56mmol) was added in portions over 2h. After stirring for 4 days at 50-60C, the reaction mixture was treated with diluted HCl under ice cooling. The pure precipitate that formed was filtered, washed with water to neutralize and dried. Yield: 1.15g (68%). M.p. 238-240C. Anal. Calc. for C16H10N2O4: C, 65.31; H, 3.43; N, 9.52; O, 21.75. Found: C, 65.20; H, 9.19; N, 3.23; O, 21.58%. FT-IR (KBr), numax/(cm-1): 3084 (Ar-CH), 2921-2851 (aliphatic CH), 2231 (C?N), 1675 (C=O), 1574-1458 (C=C), 1277 (Ar-O-Ar), 1247, 1182, 983, 756, 650, 509, 456. 1H NMR (d-DMSO 500MHz, delta ppm): 7.81 (dd, 1H, Ar-H), 7.76 (t, 1H, Ar-H), 7.49 (dd, 1H, Ar-H), 7.12 (dd, 1H, Ar-H), 7.64 (dd, 1H, Ar-H), 7.69 (s, 1H, Ar-H), 3.79 (s, 3H, OCH3). UV-Vis lambdamax (nm) (log epsilon) in DMSO: 297 (4.35).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Nitrophthalonitrile, and friends who are interested can also refer to it.
Reference:
Article; Oezguel, Gamze; Ta?temel, Ay?eguel; Oezkaya, Ali Riza; Bulut, Mustafa; Polyhedron; vol. 85; (2015); p. 181 – 189;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts