Electric Literature of 4426-11-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4426-11-3 as follows.
Example 44B l-(l-(3-chlorophenyl)ethyl)cyclobutanecarbonitrile n-BuLi (4.7 mL, 11.8 mmol, 2.5 M in hexane) was added to a solution ofdiisopropylamine (1.13 g, 11.2 mmol) in THF (20 mL) at -78C. After stirring for 5 min, neat cyclobutancarbonitrile (0.8 g, 9.87 mmol) was added and the mixture was stirred at -78C for 1 hour. Then a solution of Example 44A (2.6 g, 11.8 mmol) in THF (10 mL) was added and the mixture was stirred at -78C for 1 h. The mixture was quenched with water and extracted with EtOAc (40 mL). The solvent was evaporated and the residue was used directly in the next step without further purification. LC-MS: m/z 220 (M+H).
According to the analysis of related databases, 4426-11-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD; BAYBURT, Erol, K.; CLAPHAM, Bruce; COX, Phil, B.; DAANEN, Jerome, F.; GOMTSYAN, Arthur; KORT, Michael, E.; KYM, Philip, R.; VOIGHT, Eric, A.; WO2012/19315; (2012); A1;,
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