Adding a certain compound to certain chemical reactions, such as: 501-00-8, name is 2-(3-Fluorophenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 501-00-8, Recommanded Product: 2-(3-Fluorophenyl)acetonitrile
Step A: Preparation of 4-(3-Fluorophenyl)-tetrahydro-2H-pyran-4-carbonitrile; [0561] Potassium tert-butoxide (5.48 g, 48.8 mmol) was added to a stirred solution of 2-(3-fluorophenyl)acetonitrile (2.58 mL, 22.2 mmol) in DMF (30 mL) at 00C under a nitrogen atmosphere. The mixture was stirred for 10 minutes at 00C before l-chloro-2-(2-chloroethoxy)ethane (2.86 mL, 24.4 mmol) was added dropwise via syringe. The reaction mixture was allowed to warm to room temperature and stirred for 6 hours. The reaction mixture was then cooled to 00C and quenched with 10% HCl. The aqueous mixture was extracted with EtOAc (2x). The combined organic layers were washed with brine, dried (MgSO4), and concentrated in vacuo to give the product as an orange oil (7.53 g)-
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Reference:
Patent; AMGEN INC.; WO2008/76427; (2008); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts