Reference of 3218-50-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3218-50-6, name is 2,5-Dichlorobenzyl cyanide belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A mixture of 2,5-dichlorobenzyl bromide (5.4 g, 22.5 mmol) in 16 mL of ethanol and potassium cyanide (1.63 g, 25 mmol) in 4 mL of water was heated at 80 C overnight, then cooled, and the solids were filtered and washed with ethanol to give 3.5 g of 2,5- dichlorophenylacetonitrile as a white powder melting at 89-91 C. The nitrile was suspended in 20 mL of ethanol, and 20 mL of a 25 % aqueous NaOH solution was added.The mixture was heated in a CEM Explore microwave reactor at 140 0C for 30 minutes, then cooled, poured into ice water and acidified to pH 1 with concentrated HCl to give a precipitate. The precipitate was filtered, washed with water and dried in a vacuum oven at90 0C for 5 h to give the title compound as a white powder. 1H NMR (CDCl3) 5 3.79 (s, 2H), 7.2-7.4 (m, 3H)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,5-Dichlorobenzyl cyanide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; WO2008/91594; (2008); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts