Adding a certain compound to certain chemical reactions, such as: 98730-77-9, name is 1-(Hydroxymethyl)cyclopropanecarbonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 98730-77-9, Computed Properties of C5H7NO
A stirred mixture of 1-(hydroxymethyl)cyclopropanecarbonitrile (24.30mmol, 2.36g) in dichloromethane (3OmL) was treated with triethylamine (48.6mmol, 6.83mL, 4.92g) and portionwise with methanesulfonyl chloride (31.6mmol, 2.445mL, 3.62g) keeping the reaction mixture at O0C. The solution was allowed to stir for 1 hour then diluted with saturated sodium hydrogencarbonate and extracted with 10% methanol/dichloromethane (x3). The organic layers were combined and concentrated under reduced pressure to give the intermediate (i-cyanocyclopropyl)methyl methanesulfonate (3.77g).1H NMR (CDCI3, 400 MHz): delta 1.18 (2H, m), 1.46 (2H, m), 3.14 (3H, s), 4.18 (2H, s)
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Reference:
Patent; N.V. ORGANON; WO2009/24550; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts