Electric Literature of 3759-28-2, The chemical industry reduces the impact on the environment during synthesis 3759-28-2, name is 2-(Cyanomethyl)benzonitrile, I believe this compound will play a more active role in future production and life.
General procedure: A solution of homophthalonitrile(129 mg, 0.820 mmol) in i-PrOH (2 ml) wastreated with salicylaldehyde (1.640 mmol) and NH4OAc(143 mg, 1.640 mmol). The mixture was placed into amicrowave reactor and heated at 150C for 10 min. Thenthe mixture was treated with pyrrole (1.640 mmol) and Et3N (0.114 ml, 0.820 mmol) and heated again in themicrowave reactor at 150C for 10 min. The solvent was distilled under reduced pressure. The solid was purified by chromatography on silica gel, eluent EtOAc-hexane,gradient from 1:4 to 1:1.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(Cyanomethyl)benzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Festa, Alexey A.; Sorokina, Elena A.; Storozhenko, Olga A.; Varlamov, Alexey V.; Voskressensky, Leonid G.; Yue, Xiaoyi; Chemistry of Heterocyclic Compounds; vol. 56; 4; (2020); p. 495 – 498; Khim. Geterotsikl. Soedin.; vol. 56; 4; (2020); p. 495 – 498,4;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts