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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 78881-21-7, name is 4-Amino-3-methylbenzonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 4-Amino-3-methylbenzonitrile

In a round-bottomed flask 4-amino-3-methylbenzonitrile (Alfa Aesar, Avocado, Lancaster; 10.88 g, 82 mmol), and Et3N (22.95 mL, 165 mmol) were stirred in DCM (200 mL) at O0C. TFAA (13.95 ml_, 99 mmol) was added slowly via a dropping funnel and the mixture stirred at room temperature for 30 min. The reaction mixture was poured into 2M HCI (150 ml_). The organic layer was then collected and then washed with a saturated solution of sodium bicarbonate (150 ml_), dried (MgSC^), filtered and the solvent was removed to give a dark yellow solid (19.37 g); m/z (ES”) 227 (M-1 );1 H NMR (400MHz, CDCI3): delta 8.43 (1 H, d), 7.91 (1 H, br s), 7.59 (1 H, dd). 7.56 (1 H, s). 2.37 (3H, s).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; GLAXO GROUP LIMITED; WO2009/127678; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts