Reference of 98730-77-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 98730-77-9 as follows.
Step 2: ( 1 -cyanocyclopropyljmethyl methane sulfonate; At r.t to a solution of l^hydroxymethyOcyclopropanecarbonitrile (0.41 g, 4.2 mmo.) in methylene chloride (10 mL) was added methanesulfonyl chloride (490 uL, 6.3 mmol), followed by triethylamine (1.5 mL, 10.0 mmol) and 4-dimethylaminopyridine (18 mg, 0.15 mmol). The mixture was stirred at r.L for 3 h. It was diluted with methylene chloride, washed with water and brine, dried over Na2SO4. After filtration the filtrate was concentrated to yield the crude product which was used in the next step reaction without further purification.
According to the analysis of related databases, 98730-77-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; INCYTE CORPORATION; ZHANG, Colin; QIAN, Ding-quan; ZHUO, Jincong; YAO, Wenqing; WO2010/75270; (2010); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts