In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6306-60-1 as follows. Product Details of 6306-60-1
EXAMPLE IV A mixture of 18.5 parts of 2,4-dichlorobenzeneacetonitrile and 180 parts of N,N-dimethylformamide is stirred and cooled in an ice-bath while nitrogen gas is introduced. 3.2 Parts of a sodium hydroxide solution 78% are added portionwise and the whole is stirred for one hour. Then there are added dropwise, during a one hour-period, 17.8 parts of (bromomethyl)cyclohexane while still cooling and while nitrogen gas is still introduced. Upon completion, stirring is continued for 2 hours at room temperature. The reaction mixture is poured onto water. The precipitated product is filtered off and triturated in a mixture of methanol and water. The product is filtered off and dried, yielding 25.5 parts of 2,4-dichloro-alpha-(cyclohexylmethyl)benzeneacetonitrile; mp. 58.8 C.
According to the analysis of related databases, 6306-60-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Janssen Pharmaceutica N.V.; US4598085; (1986); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts